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Titolo:
Metabolic consequences of growth hormone treatment in paediatric practice
Autore:
Saenger, P;
Indirizzi:
Albert Einstein Coll Med, Montefiore Med Ctr, Div Pediat Endocrinol, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 docrinol, Bronx, NY 10467 USA
Titolo Testata:
HORMONE RESEARCH
, volume: 53, anno: 2000, supplemento:, 1
pagine: 60 - 69
SICI:
0301-0163(2000)53:<60:MCOGHT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC SHORT STATURE; BENIGN INTRACRANIAL HYPERTENSION; CHRONIC RENAL-INSUFFICIENCY; TURNER SYNDROME; HYPOPITUITARY CHILDREN; INSULIN SENSITIVITY; LIPID-METABOLISM; BODY-COMPOSITION; DEFICIENCY; GLUCOSE;
Keywords:
growth hormone; carbohydrate tolerance; water retention; hyperlipidaemia; carpal tunnel syndrome; idiopathic intracranial hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Saenger, P Albert Einstein Coll Med, Montefiore Med Ctr, Div Pediat Endocrinol, 111 E210th St, Bronx, NY 10467 USA Albert Einstein Coll Med 111 E 210th St Bronx NY USA 10467 USA
Citazione:
P. Saenger, "Metabolic consequences of growth hormone treatment in paediatric practice", HORMONE RES, 53, 2000, pp. 60-69

Abstract

No metabolic side-effects of clinical significance have been reported during a 5-year study of growth hormone (GH) therapy in children with GH deficiency, Turner syn drome, idiopathic short stature or chronic renal insufficiency. In particular, insulin levels increase but remain within the normal range, as do glucose and haemoglobin A(1c). A recent study showed that the effects of growth on insulin sensitivity in prepubertal children with idiopathic short stature represent the changes in carbohydrate tolerance observedduring normal adolescence. Thus, GH treatment may lead to prolongation of the physiological state of insulin resistance observed in normal puberty. Insulin levels during the fasting state and 2 h after a standard glucose load showed no further rise after the first 3 years of continuous GH therapy. The hyperinsulinaemia observed during GH therapy may, therefore, amplify the anabolic effects of insulin on protein metabolism during puberty. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:53:20