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Titolo:
ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family
Autore:
Clark, ME; Kelner, GS; Turbeville, LA; Boyer, A; Arden, KC; Maki, RA;
Indirizzi:
Neurocrine Biosci Inc, Dept Mol Biol, San Diego, CA 92121 USA Neurocrine Biosci Inc San Diego CA USA 92121 iol, San Diego, CA 92121 USA Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 nc Res, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
GENOMICS
fascicolo: 3, volume: 67, anno: 2000,
pagine: 343 - 350
SICI:
0888-7543(20000801)67:3<343:AANMOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; RENAL-CELL CARCINOMA; EXTRACELLULAR-MATRIX; METALLOPROTEINASE-DISINTEGRIN; TNF-ALPHA; PROTEIN; THROMBOSPONDIN-1; ANGIOGENESIS; CLONING; DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, ME Neurocrine Biosci Inc, Dept Mol Biol, 10555 Sci Ctr Dr, San Diego, CA 92121 USA Neurocrine Biosci Inc 10555 Sci Ctr Dr San Diego CA USA 92121 SA
Citazione:
M.E. Clark et al., "ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family", GENOMICS, 67(3), 2000, pp. 343-350

Abstract

ADAM-TS/metallospondin genes encode a new family of proteins with structural homology to the ADAM metalloprotease-disintegrin family. However, unlikeother ADAMs, these proteins contain thrombospondin type 1 (TSP1) repeats at the carboxy-terminal end and are secreted proteins instead of being membrane bound. Members of the ADAM-TS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and theinhibition of angiogenesis, We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9, This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-terminal TSP1-like submotifs, Tn contrast; to other ADAM-TS family members, ADAMTS9 is expressed in all fetal tissues examined as well as some adult tissues. Using FISH and radiation hybrid analysis, we have localized ADAMTS9 to chromosome 3p14.2-p14.3, an area known to be lost in hereditary renal tumors. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:21:42