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Titolo:
The cloning and nucleotide sequence of human ST2L cDNA
Autore:
Li, HJ; Tago, K; Lo, KC; Kuroiwa, K; Arai, T; Iwahana, H; Tominaga, S; Yanagisawa, K;
Indirizzi:
Jichi Med Sch, Dept Biochem, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan Sci Univ Tokyo, Fac Sci & Technol, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan Sci Univ Tokyo Noda Chiba Japan 2788510 l Sci, Noda, Chiba 2788510, Japan
Titolo Testata:
GENOMICS
fascicolo: 3, volume: 67, anno: 2000,
pagine: 284 - 290
SICI:
0888-7543(20000801)67:3<284:TCANSO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1 RECEPTOR FAMILY; HELPER T-CELLS; PROMOTER USAGE; IL-1 RECEPTOR; GENE; EXPRESSION; T1/ST2; PROTEIN; PRODUCT; MEMBER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Yanagisawa, K Jichi Med Sch, Dept Biochem, 3311-1 Yakushiji, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch 3311-1 Yakushiji Minami Kawachi Tochigi Japan 3290498
Citazione:
H.J. Li et al., "The cloning and nucleotide sequence of human ST2L cDNA", GENOMICS, 67(3), 2000, pp. 284-290

Abstract

The ST2 gene is a member of the IL-1 receptor family and is hypothesized to be involved in helper T cell function, but its functional ligand and physiological pole remain unknown. We have cloned the human ST2L cDNA that encodes a distinct type of membrane-bound ST2 protein. The predicted 556-amino-acid sequence showed 67% identity to the mouse STSL protein. The human ST2 gene (IL1RL1) contains 13 exons and spans 40 kb in length. Its exon-intron organization was elucidated from a registered human genomic sequence derived from chromosome 2q, which contains three other genes belonging to the IL-1 receptor family in an approximately 202-kb genomic region. The tissue distribution of ST2 expression was examined by RT-PCR, and the soluble form (ST2, IL1RL1-a) and STSL (IL1RL1-b) appear to be expressed differentially. Wealso established stable transfectants of a human glioblastoma cell line, T98G, that express human STSL constitutively, and we confirmed cell-surface expression of human STSL protein on the transfectants. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:12:26