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Titolo:
Nitric oxide (NO)-related pharmaceuticals: Contemporary approaches to therapeutic NO modulation
Autore:
Janero, DR;
Indirizzi:
NitroMed Inc, Bedford, MA 01730 USA NitroMed Inc Bedford MA USA 01730NitroMed Inc, Bedford, MA 01730 USA
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 10, volume: 28, anno: 2000,
pagine: 1495 - 1506
SICI:
0891-5849(20000515)28:10<1495:NO(PCA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; BALLOON ANGIOPLASTY; NITROGEN MONOXIDE; SYNTHASE; DONORS; INJURY; DYSFUNCTION; INHIBITORS; RESTENOSIS; MECHANISMS;
Keywords:
free radical; nitric oxide; sexual dysfunction; restenosis; nonsteroidal anti-inflammatory drug; gastrointestinal toxicity; drug discovery and development; pharmaceuticals;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Janero, DR NitroMed Inc, 12 Oak Pk Dr, Bedford, MA 01730 USA NitroMed Inc 12 Oak Pk Dr Bedford MA USA 01730 rd, MA 01730 USA
Citazione:
D.R. Janero, "Nitric oxide (NO)-related pharmaceuticals: Contemporary approaches to therapeutic NO modulation", FREE RAD B, 28(10), 2000, pp. 1495-1506

Abstract

The biologically important gaseous radical, nitric oxide (NO), is a versatile chemical entity that enters into regulatory, protective, and adverse interactions with biomolecules and cells, in some cases through NO-derived nitrogen oxide species. Both excess tissue NO and its insufficiency have beenimplicated in the genesis or evolution of several important disease states. The associated medical needs and commercial opportunities have fostered attempts to modulate tissue NO tone for symptomatic benefit or therapeutic gain. State-of-the-art strategies for NO modulation in contemporary drug discovery and development encompass sexual dysfunction, cardiovascular, and antiinflammatory indications. Increased understanding of NO's physiological chemistry and ways to target its pharmacology appear critical to the successful clinical exploitation of NO's diverse properties. Integration of research on both the basic science of NO's mechanistic biology and the applied science of drug discovery and development represents a millennium mandate to the pharmaceutical industry in the area of NO-related therapeutics. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:51:40