Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Therapeutic and chemical developments of cholecystokinin receptor ligands
Autore:
de Tullio, P; Delarge, J; Pirotte, B;
Indirizzi:
Univ Liege, CHU, Dept Med Chem, B-4000 Liege, Belgium Univ Liege Liege Belgium B-4000 HU, Dept Med Chem, B-4000 Liege, Belgium
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 1, volume: 9, anno: 2000,
pagine: 129 - 146
SICI:
1354-3784(200001)9:1<129:TACDOC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CCK-B ANTAGONISTS; ANTIGASTRIN ACTIVITY RELATIONSHIPS; DECREASES FOOD-INTAKE; ACID-DERIVATIVES; PHARMACOLOGICAL PROFILE; BIOLOGICAL PROPERTIES; TERMINAL FRAGMENTS; NUCLEUS-ACCUMBENS; GASTRIC FUNCTION; GUINEA-PIG;
Keywords:
brain-gut hormone; cholecystokinin; CCK-A receptor; CCK-B receptor; CCK-receptors agonists; CCK-receptors antagonists; CNS disorders; pancreatic diseases; gastrointestinal disorders;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
109
Recensione:
Indirizzi per estratti:
Indirizzo: de Tullio, P Univ Liege, CHU, Dept Med Chem, Ave Hop 1, B-4000 Liege, Belgium Univ Liege Ave Hop 1 Liege Belgium B-4000 000 Liege, Belgium
Citazione:
P. de Tullio et al., "Therapeutic and chemical developments of cholecystokinin receptor ligands", EXPERT OP I, 9(1), 2000, pp. 129-146

Abstract

Cholecystokinin (CCK) is an important 'brain-gut' hormone located both in the gastrointestinal (GI) system and in the CNS. At least two different G-coupled high affinity receptors have been identified: the CCK-A and the CCK-B receptors. Although the complex biological role of CCK is, as yet, not fully understood, its connection with many different physiological processes both at the GI level and at the CNS level is now well established There is much potential for therapeutic use of CCK receptor ligands, however, clear investigations have yet to be completed. Several chemical families have been investigated over the last 20 years to find potent, subtype selective andstable CCK receptor agonists and antagonists. The main goal was to discover new therapeutic drugs acting on GI and/or on CNS diseases and also, to obtain powerful pharmacological tools that could permit a better understanding of the biological role of CCK. Despite promising results from investigations into medicinal chemistry of CCK receptor ligands, the therapeutical applications of these ligands still remains to be defined. This article reviews the main biological role of CCK, the therapeutic potential of CCK-A and CCK-B receptor agonists and antagonists and the common compounds from the different families of ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:25:14