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Titolo:
Necatoriasis: treatment and developmental therapeutics
Autore:
Georgiev, VS;
Indirizzi:
NIAID, NIH, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892NIAID, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 5, volume: 9, anno: 2000,
pagine: 1065 - 1078
SICI:
1354-3784(200005)9:5<1065:NTADT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUTANEOUS LARVA-MIGRANS; MEMBRANE GLYCOPROTEIN-IIB; HUMAN HOOKWORM INFECTIONS; PAPUA-NEW-GUINEA; AMERICANUS INFECTION; TRICHURIS-TRICHIURA; IRON-DEFICIENCY; INTESTINAL HELMINTHIASIS; ANCYLOSTOMA-CEYLANICUM; PLATELET ACTIVATION;
Keywords:
albendazole; Ancylostoma duodenale; cutaneous larva migrans; drug resistance; iron-deficiency anaemia; ivermectin; mebendazole; Necator americanus; necatoriasis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Georgiev, VS NIAID, NIH, 7600-B Rockledge Dr,Room 2102, Bethesda, MD 20892USA NIAID 7600-B Rockledge Dr,Room 2102 Bethesda MD USA 20892 USA
Citazione:
V.S. Georgiev, "Necatoriasis: treatment and developmental therapeutics", EXPERT OP I, 9(5), 2000, pp. 1065-1078

Abstract

Two hookworm parasites, Necator americanus and Ancylostoma duodenale, infect approximately one billion people worldwide. These hookworms are one of the leading causes of iron-deficiency anaemia especially in children, resulting directly from intestinal capillary blood loss following the feeding activities of fourth-stage (L-4) larva and adult worms. If ignored, human hookworm infections caa retard growth and the intellectual development of children. Another clinical manifestation often associated with hookworm infections is cutaneous larva migrans (CLM). It is a well recognised, usually self-limiting condition caused by the infectious larvae of nematodes, especiallyAncylostoma spp. CLM is characterised by skin eruption and represents a clinical description rather than a definitive diagnosis. Of the hookworm parasites, the dog and cat worm A. braziliense and A. caninum are the most common nematodes causing CLM, although many other species have also been implicated. The major subject of this review article will be discussion of the evolution of therapies and treatment of human necatoriasis and the development of experimental infections with N. americanus. Difference in the clinicalefficacy of mebendazole and albendazole will be discussed along with drug resistance of N. americanus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:25:06