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Titolo:
Interictal hippocampal benzodiazepine receptors in temporal lobe epilepsy:comparison with coregistered hippocampal metabolism and volumetry
Autore:
Szelies, B; Weber-Luxenburger, G; Mielke, R; Pawlik, G; Kessler, J; Pietrzyk, U; Bauer, B; Heiss, WD;
Indirizzi:
Max Planck Inst Neurol Forsch, D-50931 Cologne, Germany Max Planck Inst Neurol Forsch Cologne Germany D-50931 1 Cologne, Germany Univ Cologne, Neurol Klin, D-50924 Cologne, Germany Univ Cologne CologneGermany D-50924 urol Klin, D-50924 Cologne, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 4, volume: 7, anno: 2000,
pagine: 393 - 400
SICI:
1351-5101(200007)7:4<393:IHBRIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 FLUMAZENIL-PET; FDG-PET; MRI; SCLEROSIS; BINDING; ATROPHY; BRAIN; AUTORADIOGRAPHY; HYPOMETABOLISM;
Keywords:
hippocampal benzodiazepine receptors; hippocampal glucose metabolism; hippocampal volumetry; positron emission tomography; temporal lobe epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Heiss, WD Max Planck Inst Neurol Forsch, Gleueler Str 50, D-50931 Cologne,Germany Max Planck Inst Neurol Forsch Gleueler Str 50 Cologne Germany D-50931
Citazione:
B. Szelies et al., "Interictal hippocampal benzodiazepine receptors in temporal lobe epilepsy:comparison with coregistered hippocampal metabolism and volumetry", EUR J NEUR, 7(4), 2000, pp. 393-400

Abstract

The significance of benzodiazepine receptor (BZR) concentration in comparison with hippocampal metabolism and volumetry was assessed in 14 patients diagnosed with temporal lobe epilepsy (TLE) without hippocampal signal change on T2-weighted magnetic resonance imaging (MRI) scans. Focus lateralization was achieved by clinical, electroencephalographic and neuropsychologicalexaminations. Three-dimensional positron emission tomography (PET) and MRIscans were coregistered for determination of hippocampal C-11-flumazenil (FMZ) binding, normalized to average cortical values for glucose metabolism (rCMR(glc)) and volume. The hippocampi were individually outlined on T1-weighted MRI. Volumes of interest (VOI) were used for calculation of asymmetries between clinically affected and unaffected sides. Eleven out of 14 TLE patients presented a significant reduction in hippocampal volume. In nine ofthese 11 patients hippocampal FMZ binding and in seven cases hippocampal CMRglc was also reduced. In two patients without hippocampal volume asymmetry FMZ binding was markedly reduced in the mesial temporal lobe appropriately to the clinically diagnosed side. In our study volumetry is therefore themost sensitive tool for the detection of hippocampal abnormality in TLE. However, in cases without hippocampal atrophy the reduction of FMZ may indicate functional impairment of BZR before neuronal loss becomes evident. Our results emphasize the complementary nature of these tests in TLE patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:24:58