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Titolo:
Changes of cytokines during the course of graft-versus-host disease following bone marrow transplantation: A case report
Autore:
Takatsuka, H; Takemoto, Y; Okada, M; Sawada, A; Katsuno, T; Wada, H; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
CYTOKINE
fascicolo: 8, volume: 12, anno: 2000,
pagine: 1225 - 1227
SICI:
1043-4666(200008)12:8<1225:COCDTC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLICATIONS;
Keywords:
allogeneic bone marrow transplantation; graft-versus-host disease; cytokine; chemokine; intercellular adhesion molecule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
H. Takatsuka et al., "Changes of cytokines during the course of graft-versus-host disease following bone marrow transplantation: A case report", CYTOKINE, 12(8), 2000, pp. 1225-1227

Abstract

Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4), Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-a, interleukin 12, and intercellular adhesion molecule-1 were elevated in the early stage of graft-versus-host disease, followed by elevation of interleukin 10 and interleukin 8, Her symptoms subsequently improved and all of these parameters became normal. The levels of thrombomodulin and plasminogen activator inhibitor type 1 showed changes that were in parallel with the clinical course. Interleukin 1 beta, interleukin 6, interleukin 2, and interferon-gamma showed no changes throughout the course of her graft-versus-host disease. These findings suggested the possibility that release of inflammatory molecules occurred at the onset of graft-versus-host disease and caused vascular endothelial damage, which led to the exacerbation of her disease. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:43:08