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Titolo:
Abnormalities of the acoustic startle reflex and reaction time in Gilles de la Tourette syndrome
Autore:
Gironell, A; Rodriguez-Fornells, A; Kulisevsky, J; Pascual, B; Riba, J; Barbanoj, M; Berthier, M;
Indirizzi:
Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Neurol Serv, E-08193 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain Univ Barcelona, Fac Psicol, Dept Personalitat, Barcelona, Spain Univ Barcelona Barcelona Spain col, Dept Personalitat, Barcelona, Spain Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Area Invest Farmacol,Inst Recerca, Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain ,Inst Recerca, Barcelona, Spain Hosp Virgen Victoria, Neurol Serv, Malaga, Spain Hosp Virgen Victoria Malaga Spain Victoria, Neurol Serv, Malaga, Spain
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 8, volume: 111, anno: 2000,
pagine: 1366 - 1371
SICI:
1388-2457(200008)111:8<1366:AOTASR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULUS;
Keywords:
Gilles de la Tourette; startle reflex; reaction time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Gironell, A Hosp Santa Creu & Sant Pau, Dept Neurol, Av SAM Claret 167, Barcelona, Spain Hosp Santa Creu & Sant Pau Av SAM Claret 167 Barcelona Spain
Citazione:
A. Gironell et al., "Abnormalities of the acoustic startle reflex and reaction time in Gilles de la Tourette syndrome", CLIN NEU, 111(8), 2000, pp. 1366-1371

Abstract

Objective: To study the startle reflex and the effect of the startle reflex stimulus over reaction time (start-react effect) in Gilles de la Tourettesyndrome (GTS). Method: Ten GTS patients and ten matched healthy volunteers underwent a simple RT paradigm (4 blocks of 50 trials). Forty acoustic startle reflex stimuli (110 dB) were randomly delivered with a 20% occurrence probability andpresented unexpectedly at the same time as the imperative stimuli of the RT. Variables of interest were: amplitude, onset latency, degree of spread and rate of habituation of the startle response, and RT and the start-react effect caused by the startle stimuli. Results: GTS patients showed a significantly higher amplitude, a major degree of spread and fewer habituation phenomena of the startle reflex. GTS patients showed poorer non statistically significant RT performance compared to controls, with a significant correlation between RT and severity of the disease. The start-react effect was significantly less pronounced in GTS patients. Conclusions: The present study confirms that GTS has an exaggerated startle reflex response and extend the spectrum of abnormalities to the start-react effect. A state of dopaminergic hyperactivity may have contributed to these results. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 26/01/20 alle ore 16:02:10