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Titolo:
Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: Clinical evidence of platelet scavenging?
Autore:
George, ML; Eccles, SA; Tutton, MG; Abulafi, AM; Swift, RI;
Indirizzi:
Inst Canc Res, Sect Canc Therapeut, Sutton SM2 5NG, Surrey, England Inst Canc Res Sutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England Mayday Univ Hosp, Dept Surg, Surrey CR7 7YE, England Mayday Univ Hosp Surrey England CR7 7YE pt Surg, Surrey CR7 7YE, England
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 8, volume: 6, anno: 2000,
pagine: 3147 - 3152
SICI:
1078-0432(200008)6:8<3147:COPASV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAIN HIGH-LEVELS; TUMOR ANGIOGENESIS; BLOOD-PLATELETS; FACTOR VEGF; EXPRESSION; LEUKOCYTES; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: George, ML Inst Canc Res, Sect Canc Therapeut, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England Inst Canc Res 15 Cotswold Rd Sutton Surrey England SM25NG land
Citazione:
M.L. George et al., "Correlation of plasma and serum vascular endothelial growth factor levels with platelet count in colorectal cancer: Clinical evidence of platelet scavenging?", CLIN CANC R, 6(8), 2000, pp. 3147-3152

Abstract

Most studies measuring circulating vascular endothelial growth factor (VEGF) have sampled serum rather than plasma. There has been much debate whether the collection of sera (which causes the activation of platelets and VEGFrelease) is a true reflection of tumor angiogenic activity or whether platelets act as scavengers of VEGF. Addressing this issue, we measured serum and plasma VEGF, before and after colorectal resection, with reference to platelet counts, Serum and plasma samples were collected from 116 colorectal cancer (CRC) and 116 control patients. Ninety CRC and 32 benign resections were performed. Both plasma and serum VEGF were significantly higher in CRCpatients (18.5 and 327 pg/ml, respectively) compared with controls (9.0 and 151.5 pg/ml, respectively; P < 0.0001), Paired serum and plasma VEGF measurements correlated in both CRC (r = 0.56) and control patients (r = 0.73; P < 0.0001), Serum and plasma VEGF levels correlated with platelet count inCRC patients (r = 0.58 and 0.44, respectively) but not in controls, Plasmaand serum VEGF levels, and VEGF concentration per platelet, increased withadvancing disease stage. The correlation of serum and plasma VEGF with platelet counts in CRC but not in benign disease may be attributable to the scavenging of VEGF from the tumor source by platelets, with plasma levels reflecting free circulating VEGF in equilibrium with platelet levels. VEGF levels in citrated plasma are low and lie close to the limits of ELISA sensitivity. We recommend that a standardized measurement of serum VEGF-normalizedby the patient's platelet count to give a value of serum VEGF per platelet-be adopted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:40:43