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Titolo:
Frequency of central nervous system involvement in primary cutaneous B-cell lymphoma
Autore:
Bekkenk, MW; Postma, TJ; Meijer, CJLM; Willemze, R;
Indirizzi:
Leiden Univ, Med Ctr, Dept Dermatol, NL-2333 ZA Leiden, Netherlands LeidenUniv Leiden Netherlands NL-2333 ZA NL-2333 ZA Leiden, Netherlands Free Univ Amsterdam Hosp, Dept Dermatol, NL-1081 HV Amsterdam, NetherlandsFree Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands Free Univ Amsterdam Hosp, Dept Neurol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1081 HV m, Netherlands
Titolo Testata:
CANCER
fascicolo: 4, volume: 89, anno: 2000,
pagine: 913 - 919
SICI:
0008-543X(20000815)89:4<913:FOCNSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; MYCOSIS-FUNGOIDES; INTRAVASCULAR LYMPHOMATOSIS; RISK-FACTORS; CLASSIFICATION; RADIOTHERAPY; ENTITY; ORIGIN; GRADE; CNS;
Keywords:
cutaneous B-cell lymphoma; central nervous system involvement; incidence; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Bekkenk, MW Leiden Univ, Med Ctr, Dept Dermatol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands Leiden Univ Albinusdreef 2 Leiden Netherlands NL-2333 ZA ands
Citazione:
M.W. Bekkenk et al., "Frequency of central nervous system involvement in primary cutaneous B-cell lymphoma", CANCER, 89(4), 2000, pp. 913-919

Abstract

BACKGROUND, Primary cutaneous B-cell lymphoma (CBCL) constitutes approximate to 20% of all primary cutaneous lymphomas. Apart from primary cutaneous large B-cell lymphoma presenting on the legs (PCLBCL-leg), primary CBCLs run an indolent clinical course, rarely disseminate to extracutaneous sites, and have an excellent prognosis. Because of recent observations in two patients who developed central nervous system (CNS) involvement, follow-up dataof all primary CBCL patients registered at the Dutch Cutaneous Lymphoma Group between 1985 and 1998 were investigated for evidence of CNS involvement. METHODS, Follow-up data from 160 primary CBCLs were evaluated. This group included 122 primary cutaneous follicle center cell lymphomas (PCFCCLs), 16primary cutaneous immunocytomas or marginal zone B-celI lymphomas, and 22 PCLBCL-leg. RESULTS, Of all 160 patients with primary CBCLs, 11 died of lymphoma, including 4 of 122 patients (3%) with PCFCCL and 7 of 22 patients (32%) with PCLBCL-leg. Four of these 11 patients, including 3 with PCFCCL and 1 with PCLBCL-leg, had developed CNS involvement 3-93 months (median, 30 months) after diagnosis. AU patients died 1-9 months (median, 7 months) after the development of CNS involvement In the group of 122 patients with PCFCCL, CNS involvement occurred in 3 of 7 patients (43%) who developed extracutaneous disease and accounted for 3 of 4 lymphoma-related deaths (75%). CONCLUSIONS. The results of this study indicate that approximately 2% of all primary CBCLs may develop CNS involvement. Whereas, in rare PCFCCL patients, developing extracutaneous disease CNS involvement was an important cause of death, patients with PCLBCL-leg and secondary CBCL died more frequently due to involvement of non-CNS organ systems. (C) 2000 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:34:46