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Titolo:
Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis
Autore:
Balasenthil, S; Saroja, M; Ramachandran, CR; Nagini, S;
Indirizzi:
Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India Annamalai Univ, Fac Sci, Dept Oral Pathol, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
fascicolo: 4, volume: 38, anno: 2000,
pagine: 267 - 270
SICI:
0266-4356(200008)38:4<267:OHAHCA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil et al., "Of humans and hamsters: comparative analysis of lipid peroxidation, glutathione, and glutathione-dependent enzymes during oral carcinogenesis", BR J ORAL M, 38(4), 2000, pp. 267-270

Abstract

We examined the extent of lipid peroxidation and the amount of reduced glutathione (GSH), and activities of the GSH-dependent enzymes, glutathione peroxidase (GPx) and glutathione S-transferase (GST), in human oral tumour tissue and 7,12-dimethylbenz[a]anthracene-(DMBA)- hamster buccal pouch tumourtissues. Diminished lipid peroxidation in the oral and hamster tumours wasaccompanied by a significant reduction in the concentration of phospholipids and an increase in the cholesterol:phospholipid ratio. The concentrationof glutathione and the activities of GPx and GST were raised in both humanoral and hamster tumour tissues. Our results show that the patterns of changes in human oral squamous cell carcinomas and chemically-induced carcinomas of the hamster buccal pouch are similar.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:39:41