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Titolo:
Dopamine release in the medial preoptic area of female rats in response tohormonal manipulation and sexual activity
Autore:
Matuszewich, L; Lorrain, DS; Hull, EM;
Indirizzi:
SUNY Buffalo, Dept Psychol, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NYUSA 14260 lo, Dept Psychol, Buffalo, NY 14260 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 4, volume: 114, anno: 2000,
pagine: 772 - 782
SICI:
0735-7044(200008)114:4<772:DRITMP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIECTOMIZED RATS; STRIATAL DOPAMINE; NUCLEUS-ACCUMBENS; EXTRACELLULAR DOPAMINE; PROGESTIN RECEPTORS; NIGROSTRIATAL TERMINALS; CATECHOLAMINE TURNOVER; TEMPORAL RELATIONSHIP; LORDOSIS REFLEX; SUBSTANCE-P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Hull, EM SUNY Buffalo, Dept Psychol, Pk Hall, Buffalo, NY 14260 USA SUNY Buffalo Pk Hall Buffalo NY USA 14260 , Buffalo, NY 14260 USA
Citazione:
L. Matuszewich et al., "Dopamine release in the medial preoptic area of female rats in response tohormonal manipulation and sexual activity", BEHAV NEURO, 114(4), 2000, pp. 772-782

Abstract

Dopamine (DA) is responsive to hormonal manipulations and has been implicated in the regulation of female rat sexual behavior. In the present studies, extracellular DA levels were assessed in the medial preoptic area (MPOA) of ovariectomized female rats in response to exogenous ovarian hormones andduring sexual activity. In female rats primed with a low dose of estradiolbenzoate (2 mu g), but not with a higher dose (20 mu g), a 500-mu g progesterone injection increased extracellular DA and facilitated copulatory behavior. Extracellular DA levels in the MPOA were further augmented during sexual interactions with a male rat in a nonpacing copulatory chamber by either perineal or vaginal stimulation. However, in a pacing chamber, DA efflux did not increase, although the metabolites rose significantly during copulation. Together, these findings suggest that extracellular DA in the MPOA responds to the hormonal state of the female rat and may contribute to her expression of sexual behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:31:32