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Titolo:
Potentiation of conditioned freezing following dorsomedial prefrontal cortex lesions does not interfere with fear reduction in mice
Autore:
Vouimba, RM; Garcia, R; Baudry, M; Thompson, RF;
Indirizzi:
Univ Bordeaux 1, CNRS UMR 5106, Cognit Neurosci Lab, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 osci Lab, F-33405 Talence, France Univ So Calif, Program Neurosci, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 eurosci, Los Angeles, CA 90089 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 4, volume: 114, anno: 2000,
pagine: 720 - 724
SICI:
0735-7044(200008)114:4<720:POCFFD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTINCTION; INHIBITION; AMYGDALA; STARTLE; BRAIN; RATS; EXCITATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Vouimba, RM Univ Bordeaux 1, CNRS UMR 5106, Cognit Neurosci Lab, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 33405 Talence, France
Citazione:
R.M. Vouimba et al., "Potentiation of conditioned freezing following dorsomedial prefrontal cortex lesions does not interfere with fear reduction in mice", BEHAV NEURO, 114(4), 2000, pp. 720-724

Abstract

In Experiment 1, an auditory conditioned stimulus (CS) was paired with footshock, except when it was preceded by another stimulus (a visual conditioned inhibitor [CI]). After conditioning, all mice displayed less CS-evoked freezing when the CI-CS compound was presented than when the CS was presented alone. However, lesions of the dorsomedial prefrontal cortex (dmPFC) potentiated CS-evoked freezing on each of the 2 sessions (i.e.. CI-CS and CS alone). In Experiment 2, mice were submitted to fear extinction (CS-alone presentation for 3 days). Lesioned mice exhibited a higher level of freezing behavior than controls on each of the 3 sessions. However, lesioned mice andcontrols displayed the same rate of reduction of freezing over the 3 days of extinction. These data in mice support previous studies in rats, which suggests that the dmPFC is not critical for either conditioned inhibition orextinction of acquired freezing behavior.

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Documento generato il 15/01/21 alle ore 21:09:13