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Titolo:
Evaluation of a rapid diagnostic test, 'Determine (TM) malaria pf', in epidemic-prone, forest villages of central India (Madhya Pradesh)
Autore:
Singh, N; Valecha, N;
Indirizzi:
ICMR, Malaria Res Ctr, Field Stn, Jabalpur 482003, India ICMR Jabalpur India 482003 ia Res Ctr, Field Stn, Jabalpur 482003, India ICMR, Malaria Res Ctr, Delhi 110054, India ICMR Delhi India 110054ICMR, Malaria Res Ctr, Delhi 110054, India
Titolo Testata:
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY
fascicolo: 5, volume: 94, anno: 2000,
pagine: 421 - 427
SICI:
0003-4983(200007)94:5<421:EOARDT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ANTIGEN-CAPTURE ASSAY; PLASMODIUM-FALCIPARUM; IMMUNOCHROMATOGRAPHIC TEST; PRESUMPTIVE DIAGNOSIS; INFECTIONS; MICROSCOPY; INDONESIA; VIVAX; AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, N ICMR, Malaria Res Ctr, Field Stn, Med Coll Bldg, Jabalpur 482003,India ICMR Med Coll Bldg Jabalpur India 482003 Jabalpur 482003, India
Citazione:
N. Singh e N. Valecha, "Evaluation of a rapid diagnostic test, 'Determine (TM) malaria pf', in epidemic-prone, forest villages of central India (Madhya Pradesh)", ANN TROP M, 94(5), 2000, pp. 421-427

Abstract

A rapid, immunochromatographic test for malaria diagnosis, 'Determine(TM) malaria pf', was evaluated by a field team in the epidemic-affected, forestsetting of Chhindwara district, in Madhya Pradesh, central India. In all, 526 fever cases were screened for Plasmodium falciparum in October or November, 1999. Those found to be infected were treated with sulfadoxine-pyrimethamine and primaquine. Using microscopy as the gold standard, the new test had a sensitivity of 98% and a specificity of 87%. The positive and negative predictive values were 88% and 98%, respectively. Although follow-up of 64 subjects on day 7 post-treatment revealed that 20% of those who then appeared smear-negative were still antigenaemic, 34% of the subjects were still smear-positive, for asexual parasites, at that rime. The Determine test was found to be very easy to perform and the results could be read reliably by field workers, without any supervision. The ease ofuse of the test indicates that it could be useful in the management of malaria, particularly in remote and inaccessible areas, provided that its accuracy can be assured and that it can be made affordable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 03:29:00