Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians
Autore:
Hutz, MH; Almeida, S; Coimbra, CEA; Santos, RV; Salzano, FM;
Indirizzi:
Univ Fed Rio Grande Sul, Inst Biociencias, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul Porto Alegre RS Brazil BR-91501970 BC, RS, Brazil FIOCRUZ, Escola Nacl Saude Publ, Dept Endemias Samuel Pessoa, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro, Museu Nacl, Dept Anthropol, Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil l, Rio De Janeiro, Brazil
Titolo Testata:
AMERICAN JOURNAL OF HUMAN BIOLOGY
fascicolo: 5, volume: 12, anno: 2000,
pagine: 638 - 645
SICI:
1042-0533(200009/10)12:5<638:HAAFFT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; TRANSPORTER GENE; RECEPTOR GENE; PHYLOGENETIC TREES; NOVELTY SEEKING; DRD2 LOCUS; ASSOCIATION; POLYMORPHISM; ALCOHOLISM; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Hutz, MH Univ Fed Rio Grande Sul, Inst Biociencias, Dept Genet, Caixa Postal 15053,BR-91501970 Porto Alegre, RS, Brazil Univ Fed Rio Grande Sul CaixaPostal 15053 Porto Alegre RS Brazil BR-91501970 BC
Citazione:
M.H. Hutz et al., "Haplotype and allele frequencies for three genes of the dopaminergic system in South American Indians", AM J HUM B, 12(5), 2000, pp. 638-645

Abstract

Haplotype and allele frequencies for the dopamine D2 receptor gene (DRD2),dopamine D4 receptor gene (DRD4), and dopamine transporter protein gene (SLC6A3) were determined in 135 individuals from five Brazilian Indian tribes, and the results integrated with those previously presented for this ethnic group. DRD2 and DRD4 were highly polymorphic. Haplotypes including TaqI A1 at DRD2, and the seven repeat allele at DRD4 were the most frequent variants, while the SLC6A3 locus was monomorphic for the 10 repeat allele in South American Indians. Genetic distances and the corresponding neighbor-joining tree indicated a geographic dichotomy beta een North + Central American and South American natives, with the exception of the Wai Wai, who live north of the Amazon river and are grouped in the northern cluster. G(ST) estimates from these genes vary between 0.05 and 0.11 for North and South America, respectively, indicating a higher degree of differentiation of the latter groups. These results are in accordance with previous genetic data on other systems, as well as with the history and biodemographical data of South American Indians. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:22:21