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Titolo:
Neuroadrenergic activation and a response to dobutamine in congestive heart failure secondary to idiopathic dilated cardiomyopathy
Autore:
Vigna, C; Fusilli, S; Natali, R; Russo, A; De Rito, V; Siena, GP; Cianfrone, N; Lombardo, A; Fanelli, R; Loperfido, F;
Indirizzi:
Catholic Univ Sacred Heart, Ist Cardiol, I-00168 Rome, Italy Catholic UnivSacred Heart Rome Italy I-00168 rdiol, I-00168 Rome, Italy IRCCS, Casa Sollievo Sofferenza Hosp, Dept Cardiol, Foggia, Italy IRCCS Foggia Italy ollievo Sofferenza Hosp, Dept Cardiol, Foggia, Italy IRCCS, Casa Sollievo Sofferenza Hosp, Dept Pathol, Foggia, Italy IRCCS Foggia Italy Sollievo Sofferenza Hosp, Dept Pathol, Foggia, Italy
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 4, volume: 86, anno: 2000,
pagine: 422 - 426
SICI:
0002-9149(20000815)86:4<422:NAAART>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; REDISTRIBUTION TL-201 TOMOGRAPHY; LEFT-VENTRICULAR DYSFUNCTION; STRESS ECHOCARDIOGRAPHY; CONTRACTILE RESERVE; MYOCARDIAL-INFARCTION; REVASCULARIZATION; VIABILITY; SURVIVAL; INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Loperfido, F Catholic Univ Sacred Heart, Ist Cardiol, Complesso Integrato Columbus,Via G Moscati 31-33, I-00168 Rome, Italy Catholic Univ Sacred Heart Complesso Integrato Columbus,Via G Moscati 31-33 Rome Italy I-00168
Citazione:
C. Vigna et al., "Neuroadrenergic activation and a response to dobutamine in congestive heart failure secondary to idiopathic dilated cardiomyopathy", AM J CARD, 86(4), 2000, pp. 422-426

Abstract

Detection of contractile reserve is important in heart failure patients. To determine if detection of contractile reserve is influenced by neuroadrenergic activation, we examined the relation between dobutamine stress echocardiography (DSE) findings and plasma norepinephrine levels (NE) at rest in 35 patients with nonischemic left ventricular (LV) dysfunction (New York Heart Association class >III in all; LV ejection fraction 0.27 +/- 0.5), Changes in global wall motion score (WMS), and separately in WMS of hypokineticsegments and akinetic segments, were analyzed, A patient was considered tobe responsive to dobutamine if the change in global WMS was greater than or equal to 4. Twenty-three patients were responsive and 12 were not responsive to dobutamine, Plasma NE and baseline heart rate were significantly higher in non-responsive patients (p <0.001). Changes in global WMS and in hypokinetic segment WMS were inversely related to either plasma NE (r -0.68 and -0.67, respectively) or baseline heart rate (r -0.60 and -0.66, respectively). The change in akinetic segment WMS was related to plasma NE only (r -0.50), Changes in WMS were not related to age, diastolic and systolic LV volume, baseline global WMS, or number of akinetic segments at baseline. Plasma NE >602 pg/ml predicted a blunted or absent contractile reserve at DSE (sensitivity 92%; specificity 87%). Neuroadrenergic activation may influencecontractile reserve found at DSE in patients with heart failure due to nonischemic LV dysfunction, (C)2000 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:28:39