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Titolo:
Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q-wave acute myocardial infarction
Autore:
Choussat, R; Montalescot, G; Collet, JP; Jardel, C; Ankri, A; Fillet, AM; Thomas, D; Raymond, J; Bastard, JP; Drobinski, G; Orfila, J; Agut, H; Thomas, D;
Indirizzi:
Hop La Pitie Salpetriere, Dept Cardiol, Biochem Lab, Paris, France Hop La Pitie Salpetriere Paris France rdiol, Biochem Lab, Paris, France Hop La Pitie Salpetriere, Dept Cardiol, Hemostasis Lab, Paris, France Hop La Pitie Salpetriere Paris France ol, Hemostasis Lab, Paris, France Hop La Pitie Salpetriere, Dept Cardiol, Virol Lab, Paris, France Hop La Pitie Salpetriere Paris France Cardiol, Virol Lab, Paris, France CHU, Bacteriol Lab, Amiens, France CHU Amiens FranceCHU, Bacteriol Lab, Amiens, France CHU, St Vincent de Paul Hosp, Bacteriol Lab, Paris, France CHU Paris France St Vincent de Paul Hosp, Bacteriol Lab, Paris, France
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 4, volume: 86, anno: 2000,
pagine: 379 - 384
SICI:
0002-9149(20000815)86:4<379:EOPETC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; C-REACTIVE PROTEIN; RISK FACTOR; INFECTION; FIBRINOGEN; ASSOCIATION; ATHEROSCLEROSIS; RESTENOSIS; TWAR; SEROPOSITIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Montalescot, G CHU Pitie Salpetriere, Dept Cardiol, 47 Blvd Hop, F-75013 Paris, France CHU Pitie Salpetriere 47 Blvd Hop Paris France F-75013 nce
Citazione:
R. Choussat et al., "Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q-wave acute myocardial infarction", AM J CARD, 86(4), 2000, pp. 379-384

Abstract

Inflammation and chronic infections may be important features in the pathogenesis of acute coronary syndromes. We describe 6 systemic markers of inflammation in patients with unstable angina or non-Q-wave myocardial infarction and the relations between these markers, seropositivity to chronic infections, and prognosis. C-reactive protein (CRP), serum amyloid A protein (SAA), fibrinogen, interleukin-6 (IL-6), neopterin, procalcitonin, and serum antibody levels to Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus were measured on admission and 48 hours later. One-year clinical follow-up was performed. Plasma levels of acute phase reactants were all elevated on admission and increased further at 48 hours: CRP from 10.1 +/- 2.1 mg/L at baseline to 26.6 +/- 5.1 mg/L at 48 hours (p <0.001); SAA from 27.3 +/- 8.5 to 93.1 +/- 23.2 mg/dl (p <0.005); fibrinogen from 3.2 +/- 0.1 to 3.8 +/- 0.1 g/L (p <0.0001); whereas initial high levels of IL-6 tended also to increase from 9.8 +/- 2 to 15.3 +/- 3.1 pg/ml (p = NS). In contrast, neopterin and procalcitonin remained unchanged. We found no association between levels of each inflammatory marker and the serologic status. Furthermore,levels of inflammatory proteins in patients seronegative to all 3 agents were comparable to those of patients seropositive to 2 or 3 infectious agents. The composite end points of death, myocardial infarction, recurrent angina, or revascularization at 1-year follow-up did not differ according to the serologic status. Thus, in patients with acute coronary syndromes, the acute phase proteins increased over the first 2 days of hospitalization. Thisinitial inflammatory reaction as well as the 1-year clinical outcome did not differ according to the initial serologic status of Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus. (C) 2000 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:50:48