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Titolo:
Outcome of infants 23-26 weeks' gestation pre and post surfactant
Autore:
Jacobs, SE; OBrien, K; Inwood, S; Kelly, EN; Whyte, HE;
Indirizzi:
Univ Toronto, Hosp Sick Children, Dept Pediat, Div Neonatol, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 natol, Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Nursing, Div Neonatol, Toronto, ON M5G 1X8, Canada UnivToronto Toronto ON Canada M5G 1X8 natol, Toronto, ON M5G 1X8, Canada Univ Toronto, Mt Sinai Hosp, Toronto, ON M5G 1X8, Canada Univ Toronto Toronto ON Canada M5G 1X8 Hosp, Toronto, ON M5G 1X8, Canada
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 8, volume: 89, anno: 2000,
pagine: 959 - 965
SICI:
0803-5253(200008)89:8<959:OOI2WG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTREMELY PREMATURE-INFANTS; RESPIRATORY-DISTRESS SYNDROME; FOLLOW-UP; BIRTH WEIGHTS; SYNTHETIC SURFACTANT; 800 GRAMS; THERAPY; SURVIVAL; BORN; LESS;
Keywords:
developmental outcome; extremely low birthweight; extremely low gestational age; mortality; prematurity; surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Whyte, HE Univ Toronto, Hosp Sick Children, Dept Pediat, Div Neonatol, 555Univ Ave,Toronto, ON M5G 1X8, Canada Univ Toronto 555 Univ Ave Toronto ON Canada M5G 1X8 1X8, Canada
Citazione:
S.E. Jacobs et al., "Outcome of infants 23-26 weeks' gestation pre and post surfactant", ACT PAEDIAT, 89(8), 2000, pp. 959-965

Abstract

To describe mortality and neurodevelopmental outcome before and after the introduction of rescue therapy with natural surfactant in two neonatal units in Toronto, Canada, a retrospective cohort study of 891 liveborn 23-26 wkgestational age infants, 421 presurfactant (1982-1987) and 470 postsurfactant (1990-1994) was performed. Overall mortality was stable over time (42% vs 35%, p = 0.077), but declined for inborn 24 (71% vs 43%, p = 0.03) and 26 wk (26% vs 13%, p = 0.01) gestational age infants and was higher in surfactant-treated infants (p < 0.0001). Chronic lung disease (61% vs 34%, p < 0.0001) and bilateral blindness (8% vs 4%, p = 0.004) declined over time, with stable rates of cerebral palsy (12% vs 15%), cognitive deficit (27% vs 26%) and aided sensorineural hearing loss (5% vs 4%). Sixty-five percent of surviving infants in both eras were free from neurodevelopmental impairment, and severe impairment declined over time (p = 0.035). This study shows no secular change in overall mortality in a large cohort of 23-26 wk gestational age the introduction of rescue therapy with naturalsurfactant. However, it does suggest that maternal transfer to and delivery of all extremely preterm infants in high risk perinatal centres is justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:01:32