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Titolo:
Pattern of deposition of stainless steel welding fume particles inhaled into the respiratory systems of Sprague-Dawley rats exposed to a novel welding fume generating system
Autore:
Yu, IJ; Kim, KJ; Chang, HK; Song, KS; Han, KT; Han, JH; Maeng, SH; Chung, YH; Park, SH; Chung, KH; Han, JS; Chung, HK;
Indirizzi:
Korea Occupat Safety Hlth Agcy, Ind Chem Res Ctr, Occupat Safety & Hlth Res Inst, Yusung Gu, Taejon 305380, South Korea Korea Occupat Safety Hlth Agcy Taejon South Korea 305380 80, South Korea Kosin Univ, Dept Pathol, Coll Med, Pusan, South Korea Kosin Univ Pusan South Korea Dept Pathol, Coll Med, Pusan, South Korea Sung Kyun Kwan Univ, Coll Pharm, Pusan, South Korea Sung Kyun Kwan Univ Pusan South Korea v, Coll Pharm, Pusan, South Korea Korea Dusturbo Inc, Seoul, South Korea Korea Dusturbo Inc Seoul South Korea a Dusturbo Inc, Seoul, South Korea Samsung Biomed Res Inst, Seoul, South Korea Samsung Biomed Res Inst Seoul South Korea Res Inst, Seoul, South Korea
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-2, volume: 116, anno: 2000,
pagine: 103 - 111
SICI:
0378-4274(20000727)116:1-2<103:PODOSS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG;
Keywords:
welding fumes; manual metal arc; stainless steel; inhalation; lung; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, IJ Korea Occupat Safety Hlth Agcy, Ind Chem Res Ctr, Occupat Safety & Hlth Res Inst, Yusung Gu, 104-8 Moonji Dong, Taejon 305380, South Korea Korea Occupat Safety Hlth Agcy 104-8 Moonji Dong Taejon South Korea 305380
Citazione:
I.J. Yu et al., "Pattern of deposition of stainless steel welding fume particles inhaled into the respiratory systems of Sprague-Dawley rats exposed to a novel welding fume generating system", TOX LETT, 116(1-2), 2000, pp. 103-111

Abstract

In order to investigate occupational diseases related to welding fume exposure, such as nasal septum perforation, pneumoconiosis and manganese intoxication, we built a welding fume exposure system that included a welding fume generator, exposure chamber and fume collector. The fume concentrations in the exposure chamber were monitored every 15 min during a 2-h exposure. Fume (mg/m(3)) concentrations of major metals, including Fe, Mn, Cr, and Ni were found to be consistently maintained. An acute inhalation toxicity study was conducted by exposing male Sprague-Dawley rats to the welding fumes generated in this apparatus by stainless steel are welding. The rats were exposed in the inhalation chamber to a welding fume with a concentration of 62 mg/m(3) total suspended particulates for 4 h. Animals were sacrificed at 4 h and at 1, 3, 7, 10, and 14 days after exposure. Histopathological examinations were conducted on the animals' upper respiratory tracts, including the nasal pathway and the conducting airway, and on the gas exchange regionincluding the alveolar ducts, alveolar sacs, and alveoli. Diameters of fume particles varied from 0.02 to 0.81 mu m and were distributed log normally, with a mean diameter of 0.1 mu m and geometric standard deviation of 1.42. Rats exposed to the welding fume for 4 h did not show any significant respiratory system toxicity. The mean particle diameter of 0.1 pm resulted in little adsorption of the welding fume particles in the upper respiratory tract. Particle adsorption took place principally in the lower respiratory tracts, including bronchioles, alveolar ducts, alveolar sacs, and alveoli. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:18:01