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Titolo:
Similarities and/or dissimilarities of CYP2D6 polymorphism in three Tunisian ethnic groups: Arabs, Berbers, Numides
Autore:
Attitallah, S; Berard, M; Belkahia, C; Bechtel, YC; Bechtel, PR;
Indirizzi:
Fac Med, Serv Pharmacol Clin, F-25030 Besancon, France Fac Med Besancon France F-25030 Pharmacol Clin, F-25030 Besancon, France CHU Charles Nicole, Serv Pharmacol, Tunis, Tunisia CHU Charles Nicole Tunis Tunisia Nicole, Serv Pharmacol, Tunis, Tunisia
Titolo Testata:
THERAPIE
fascicolo: 3, volume: 55, anno: 2000,
pagine: 355 - 360
SICI:
0040-5957(200005/06)55:3<355:SADOCP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE HYDROXYLATION; GENETIC-POLYMORPHISM; TURKISH POPULATION; 4-HYDROXYLATION; METABOLISM; SPARTEINE; OXIDATION; JORDANIANS;
Keywords:
CYP2D6; phenotype; debrisoquine polymorphic oxidation; Tunisian ethnicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Bechtel, PR Fac Med, Serv Pharmacol Clin, Pl St Jacques, F-25030 Besancon,France Fac Med Pl St Jacques Besancon France F-25030 esancon, France
Citazione:
S. Attitallah et al., "Similarities and/or dissimilarities of CYP2D6 polymorphism in three Tunisian ethnic groups: Arabs, Berbers, Numides", THERAPIE, 55(3), 2000, pp. 355-360

Abstract

Using the validated probe drug debrisoquine and the 8 h urinary metabolic ratio debrisoquine/4 hydroxy-debrisoquine, we have determined the phenotypeof the debrisoquine CYP2D6 dependent polymorphic metabolism in 464 Arabs, 227 Berbers and 215 Numides to elicit similarities or dissimilarities of poor metabolizer (PM) prevalence. We found 2.36 per cent of PM in Arabs, 3.08per cent in Berbers and 2.33 per cent in Numides. These figures are similar to those observed in Middle East populations, and cannot be considered asdifferent from those observed in Caucasians.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:17:06