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Titolo:
Anxiolytic profile of ropinirole in the rat, mouse and common marmoset
Autore:
Rogers, DC; Costall, B; Domeney, AM; Gerrard, PA; Greener, M; Kelly, ME; Hagan, JJ; Hunter, AJ;
Indirizzi:
SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England Univ Bradford, Sch Pharm, Bradford BD7 1DP, W Yorkshire, England Univ Bradford Bradford W Yorkshire England BD7 1DP , W Yorkshire, England Neurofit SA, Preclin Res, F-67400 Illkirch, France Neurofit SA Illkirch France F-67400 reclin Res, F-67400 Illkirch, France
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 1, volume: 151, anno: 2000,
pagine: 91 - 97
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; PARKINSONS-DISEASE; DOPAMINE; ANXIETY; STRESS; AGONIST; DEPRESSION; RECEPTORS; RELEASE; MODEL;
Keywords:
ropinirole; dopamine agonist; anxiety; mouse; rat; marmoset;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Rogers, DC SmithKline Beecham Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW nd
Citazione:
D.C. Rogers et al., "Anxiolytic profile of ropinirole in the rat, mouse and common marmoset", PSYCHOPHAR, 151(1), 2000, pp. 91-97

Abstract

Rationale: Some features of Parkinson's disease are exacerbated by stress and anxiety and it is important to understand the effects of dopamine receptor agonists on measures of anxiety. The aim of this study was to assess the effects of the dopamine D-2/D-3 receptor agonist ropinirole in models of anxiety and depression in the rat, mouse and marmoset. Results: In the rat elevated plus-maze test, ropinirole (0.01-1 mg/kg, i.p.) produced an inverted-U dose-response curve in the percentage time spent in the open arms. Compared with vehicle, ropinirole (0.1 mg/kg) had a significant anxiolytic-like effect, which was similar to that observed with 1.5 mg/kg diazepam. This effect was found at doses that did not affect motor behaviour or induce stereotypy. In the mouse blade and white box test of anxiety, ropinirole (0.1-10 mg/kg, i.p.) increased both the rearing time and number of line crosses in the whits section. This effect reached statistical significance for bothmeasures at a dose of 0.1 mg/kg and suggests an anxiolytic-like action of the compound. By contrast, the dopamine agonist bromocriptine (0.1-10 mg/kg, i.p.) did not produce significant changes in these behaviours. In the marmoset human threat test, ropinirole (0.01-10 mu g/kg, s.c.) reduced the number of postures at all doses tested and this reached statistical significance at 10 mu g/kg. Ropinirole did not compromise the effect of amitriptylinein the Porsolt test of depression and in itself produced antidepressant-like effects. Conclusions: These data demonstrate that systemic administration of ropinirole produces anxiolytic-like effects ill three separate models in the mouse, rat and marmoset. This may predict an action of ropinirole inman that would provide a superior profile of action over other presently available anti-parkinsonian agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:36:25