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Titolo:
DISTRIBUTION OF CA2-PERMEABLE AMPA RECEPTORS AMONG CULTURED RAT CEREBELLAR GRANULE CELLS()
Autore:
SAVIDGE JR; BRISTOW DR;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,DIV NEUROSCI,1-124 STOPFORD BLDG,OXFORD RD MANCHESTER M13 9PT LANCS ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 8, volume: 8, anno: 1997,
pagine: 1877 - 1882
SICI:
0959-4965(1997)8:8<1877:DOCARA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURKINJE-CELLS; NEURONS; EXPRESSION; EXCITOTOXICITY; ENTRY;
Keywords:
AMPA RECEPTOR; CA2+ PERMEABILITY; CEREBELLAR GRANULE CELL; CYCLOTHIAZIDE; GLUR-2 SUBUNIT; MN2+ QUENCH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Savidge e D.R. Bristow, "DISTRIBUTION OF CA2-PERMEABLE AMPA RECEPTORS AMONG CULTURED RAT CEREBELLAR GRANULE CELLS()", NeuroReport, 8(8), 1997, pp. 1877-1882

Abstract

SOME AMPA receptors are permeable to Ca2+. It has been suggested thatcultured rat cerebellar granule cells express Ca2+-permeable AMPA receptors, but their distribution at a single cell level is unknown. We report that AMPA (in the presence of cyclothiazide) induced Ca2+ entry (measured by Mn2+ quench of fura-2 fluorescence) and intracellular Ca2 increases in cerebellar granule cells in the absence of extracellular Na+, supporting the presence of Ca2+-permeable AMPA receptors. Analysis of intracellular Ca2+ signals in single cells demonstrated a heterogeneous distribution of Ca2+-permeable AMPA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:35:20