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Titolo:
Renovascular disease and hypertension in children with neurofibromatosis
Autore:
Fossali, E; Signorini, E; Intermite, RC; Casalini, E; Lovaria, A; Maninetti, MM; Rossi, LN;
Indirizzi:
Univ Milan, Ist Clin Perfez, Clin Marchi, Clin Pediat 2, I-20121 Milan, Italy Univ Milan Milan Italy I-20121 rchi, Clin Pediat 2, I-20121 Milan, Italy Univ Milan, Ist Clin Perfez, Serv Radiodiagnost & Radioterapia, I-20121 Milan, Italy Univ Milan Milan Italy I-20121 nost & Radioterapia, I-20121 Milan, Italy Osped Maggiore, IRCCS, Serv Radiol, I-20122 Milan, Italy Osped Maggiore Milan Italy I-20122 CS, Serv Radiol, I-20122 Milan, Italy Univ Milan, Ist Clin Perfez, Clin Marchi, Clin Pediat 1, I-20121 Milan, Italy Univ Milan Milan Italy I-20121 rchi, Clin Pediat 1, I-20121 Milan, Italy
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 8-9, volume: 14, anno: 2000,
pagine: 806 - 810
SICI:
0931-041X(200008)14:8-9<806:RDAHIC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-ARTERY STENOSIS; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; DOPPLER ULTRASOUND; CAPTOPRIL TEST; DIAGNOSIS; CHILDHOOD; SECONDARY;
Keywords:
hypertension; renal artery stenosis; percutaneous transluminal angioplasty neurofibromatosis type 1; ambulatory blood pressure monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fossali, E Univ Milan, Ist Clin Perfez, Clin Marchi, Clin Pediat 2, Via COmmenda 19, I-20121 Milan, Italy Univ Milan Via COmmenda 19 Milan Italy I-20121 21 Milan, Italy
Citazione:
E. Fossali et al., "Renovascular disease and hypertension in children with neurofibromatosis", PED NEPHROL, 14(8-9), 2000, pp. 806-810

Abstract

Neurofibromatosis type 1 (NF1) is associated with vascular lesions, such as renal artery stenosis, and secondary hypertension. The real prevalence islargely unknown particularly in children. We observed 27 patients with NF1, mean age 12.8 years (range 4.2-24 years), for 2-10 years to assess the association of NF1 with vascular abnormalities and secondary hypertension. Patients were studied with angiography, 24-h blood pressure monitoring, a captopril test, and Doppler ultrasonography of aorta and renal arteries. The prevalence of hypertension was 18.5%; 61.5% of patients studied with angiography had vascular lesions, half of whom were apparently normotensive. However; they had abnormal 24-h blood pressure monitoring, which was a first sign of poor blood pressure control. Those patients with severe hypertension (11.1%) were successfully treated with percutaneous transluminal angioplasty(PTA): stenosis recurred in 2 of 3 patients after a 2-year follow-up period, and was responsive to drugs. We conclude that hypertension is a frequentcomplication of NF1 in pediatric patients, it is usually secondary to typical vascular lesions, and requires careful follow-up Ambulatory blood pressure monitoring (24-h) is a sensitive method for detecting initial alterations of the blood pressure pattern. PTA may be an effective treatment in thiscondition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:44:13