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Titolo:
Evidence for 'order' in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues
Autore:
Reed, E; Dabholkar, M; Thornton, K; Thompson, C; Yu, JJ; Bostick-Bruton, F;
Indirizzi:
NCI, Med Ovarian Canc Sect, Med Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 c Sect, Med Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 5, volume: 7, anno: 2000,
pagine: 1123 - 1128
SICI:
1021-335X(200009/10)7:5<1123:EF'ITA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTRAND CROSS-LINKS; A XERODERMA-PIGMENTOSUM; YEAST DNA-REPAIR; ERCC1; EXPRESSION; CELLS; HELICASES; MUTATION; PROTEINS; NUCLEASE;
Keywords:
nucleotide excision repair; ovarian cancer; ERCC1; XPB; CSB; XPA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Reed, E NCI, Med Ovarian Canc Sect, Med Branch, NIH, 9000 Rockville Pike,Bldg 10,Rm 12N226, Bethesda, MD 20892 USA NCI 9000 Rockville Pike,Bldg 10,Rm12N226 Bethesda MD USA 20892 SA
Citazione:
E. Reed et al., "Evidence for 'order' in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues", ONCOL REP, 7(5), 2000, pp. 1123-1128

Abstract

Nucleotide excision repair (NER) is the DNA repair pathway through which cisplatin-DNA intrastrand adduct is repaired. Clinical studies have shown that increased mRNA expression of selected genes involved in the rate-limiting step of NER, appear to be closely associated with clinical resistance to platinum agents. These specific studies have led to the possibility of an assessment of the order in which, the appearance of mRNAs of selected NER genes may occur. Included in this assessment are ERCC1, XPB, CSB, and XPA, studied in 28 ovarian cancer tumor tissue specimens. The study of these four genes, in pairs, from 28 ovarian cancer specimens, results in 168 separate observations. Based on the mRNA expression patterns of these genes in thesetissues, it is suggested that ERCC1 mRNA may appear before the mRNA of anyof the other genes, in an obligate fashion. This is followed by XPB mRNA; which appears before the mRNA of XPA; which in turn, may appear before CSB. This pattern is consistent with what we have reported previously, in non-malignant human bone marrow specimens from a cohort of 52 patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/07/18 alle ore 04:03:30