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Titolo:
ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes
Autore:
Satoh, K; Suzuki, N; Yokota, H;
Indirizzi:
Daiichi Pharmaceut Co Ltd, Tokyo Res & Dev Ctr, Discovery Res Lab, EdogawaKu, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd Tokyo Japan 1348630 waKu, Tokyo 1348630, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 289, anno: 2000,
pagine: 177 - 180
SICI:
0304-3940(20000811)289:3<177:A(DAMW>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; MATRIX METALLOPROTEINASES; EXTRACELLULAR-MATRIX; CULTURED ASTROCYTES; PROTEIN; CLONING; FAMILY; PROTEOGLYCAN; CARTILAGE; SYSTEM;
Keywords:
beta-amyloid; Alzheimer's disease; A disintegrin and metalloproteinase with thrombospondin motifs-4; rat astrocyte; cDNA subtraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, K Daiichi Pharmaceut Co Ltd, Tokyo Res & Dev Ctr, Discovery Res Lab, EdogawaKu, 1-16-13 Kitakasai, Tokyo 1348630, Japan Daiichi Pharmaceut Co Ltd 1-16-13 Kitakasai Tokyo Japan 1348630
Citazione:
K. Satoh et al., "ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes", NEUROSCI L, 289(3), 2000, pp. 177-180

Abstract

Beta-amyloid (A beta) deposition is considered to be of the most crucial events in the onset of Alzheimer's disease (AD). To identify factors involved in the exacerbation of AD, we investigated transcriptionally A beta-induced genes using a cDNA subtraction technique in rat astrocytes as previouslyreported. One subtracted gene that showed the A beta-induced expression was rat ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs). In this report, we present the deduced sequence for the mature form of rat ADAMTS-4 and demonstrate the induction of its mRNA by treatment of cells with A beta. Our results suggest a degradation of the extracellular matrix occurring in the brain of AD patients and a possibly significant role of this enzyme in the progression of AD. (C) 2000 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:19:49