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Titolo:
X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats
Autore:
Tada, E; Parent, JM; Lowenstein, DH; Fike, JR;
Indirizzi:
Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143 USA UnivCalif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Radiat Oncol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Neurosci Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 99, anno: 2000,
pagine: 33 - 41
SICI:
0306-4522(2000)99:1<33:XCAPRI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RADIATION-INDUCED APOPTOSIS; INDUCED COGNITIVE DYSFUNCTION; IONIZING-RADIATION; GRANULE CELLS; STEM-CELLS; PRENATAL IRRADIATION; CRANIAL IRRADIATION; BRAIN IRRADIATION; RAY-IRRADIATION;
Keywords:
hippocampus; rat; irradiation; apoptosis; precursor cell; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Fike, JR Univ Calif San Francisco, Dept Neurosurg, San Francisco, CA 94143USA Univ Calif San Francisco San Francisco CA USA 94143 CA 94143 USA
Citazione:
E. Tada et al., "X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats", NEUROSCIENC, 99(1), 2000, pp. 33-41

Abstract

The effects of X-irradiation on proliferating cells in the dentate subgranular zone were assessed in young adult Fisher 344 rats exposed to a range of X-ray doses and followed for up to 120 days. Apoptosis was quantified using morphology and end-labeling immunohistochemistry, and cell proliferationwas detected using antibodies against the thymidine analog BrdU and the cyclin-dependent kinase p34(cdc2). Radiation-induced apoptosis occurred rapidly, with maximum morphological and end-labeling changes observed 3-6 h after irradiation. Twenty-four hours after irradiation cell proliferation was significantly reduced relative to sham-irradiated controls. The number of apoptotic nuclei increased rapidly with radiation dose, reaching a plateau atabout 3 Gy. The maximum number of apoptotic nuclei was substantially higher than the number of proliferating cells, suggesting that nonproliferating as well as proliferating cells in the subgranular zone were sensitive to irradiation. Subgranular zone cell proliferation was significantly reduced relative to age-matched controls 120 days after doses of 5 Gy or higher. These findings suggest that neural precursor cells of the dentate gyrus are very sensitive to irradiation and an not capable of repopulating the subgranular zone at least up to 120 days after irradiation. This may help explain, in part, how ionizing irradiation induces cognitive impairments in animals and humans. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 14/07/20 alle ore 13:16:15