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Titolo:
Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns
Autore:
Staiger, JF; Bisler, S; Schleicher, A; Gass, P; Stehle, JH; Zilles, K;
Indirizzi:
Univ Dusseldorf, C&O Vogt Inst Hirnforsch, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Mannheim, Zent Inst Seel Gesundheit, Mannheim, Germany Univ MannheimMannheim Germany Inst Seel Gesundheit, Mannheim, Germany Univ Frankfurt, Inst Anat 2, Frankfurt, Germany Univ Frankfurt FrankfurtGermany kfurt, Inst Anat 2, Frankfurt, Germany KFA Julich GmbH, Forschungszentrum, Inst Med, Julich, Germany KFA Julich GmbH Julich Germany chungszentrum, Inst Med, Julich, Germany
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 99, anno: 2000,
pagine: 7 - 16
SICI:
0306-4522(2000)99:1<7:EOANEL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE-EARLY GENES; MESSENGER-RNA EXPRESSION; SOMATIC SENSORY CORTEX; SOMATOSENSORY CORTEX; ADULT-RAT; C-FOS; TACTILE DISCRIMINATION; SYNAPTIC PLASTICITY; BASAL EXPRESSION; EARLY REPRESSOR;
Keywords:
c-Fos; ICER; somatosensory cortex; stimulus-transcription coupling; enriched environment; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Staiger, JF Univ Dusseldorf, C&O Vogt Inst Hirnforsch, Univ Str 1, D-40225Dusseldorf,Germany Univ Dusseldorf Univ Str 1 Dusseldorf Germany D-40225 Germany
Citazione:
J.F. Staiger et al., "Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns", NEUROSCIENC, 99(1), 2000, pp. 7-16

Abstract

Tactile information acquired through the vibrissae is of high behavioral relevance for rodents. Numerous physiological studies have shown adaptive plasticity of cortical receptive field properties due to stimulation and/or manipulation of the whiskers. However, the cellular mechanisms leading to these plastic processes remain largely unknown. Although genomic responses are anticipated to take place in this sequel, virtually no data so far exist for freely behaving animals concerning this issue. Thus, adult rats were placed overnight in an enriched environment and most of them were also subjected to clipping of different sets of whiskers. This type of stimulation ledto a specific and statistically significant increase in the expression of the protein products of the inducible transcription factors c-Fos, JunB, inducible cyclic-AMP early repressor and Krox-24 (also frequently named Zif268 or Egr-1), but not c-Jun. The response was found in columns of the barrelcortex corresponding to the stimulated vibrissae; it displayed a layer-specific pattern. However, no induction of transcription factors was observed in the subcortical relay stations of the whisker-to-barrel pathway, i.e, the trigeminal nuclei and the ventrobasal complex. These results strongly suggest that a coordinated transcriptional responseis initiated in the barrel cortex as a consequence of processing of novel environmental stimuli. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:41:27