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Titolo:
Statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy
Autore:
Van Bogaert, P; Massager, N; Tugendhaft, P; Wikler, D; Damhaut, P; Levivier, M; Brotchi, J; Goldman, S;
Indirizzi:
Free Univ Brussels, Hop Erasme, PET Biomed Cyclotron Unit, B-1000 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1000 nit, B-1000 Brussels, Belgium Free Univ Brussels, Hop Erasme, Dept Pediat Neurol, B-1000 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1000 rol, B-1000 Brussels, Belgium Free Univ Brussels, Hop Erasme, Dept Neurosurg, B-1000 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1000 urg, B-1000 Brussels, Belgium Free Univ Brussels, Hop Erasme, Dept Neurol, B-1000 Brussels, Belgium FreeUniv Brussels Brussels Belgium B-1000 rol, B-1000 Brussels, Belgium
Titolo Testata:
NEUROIMAGE
fascicolo: 2, volume: 12, anno: 2000,
pagine: 129 - 138
SICI:
1053-8119(200008)12:2<129:SPMORG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; COMPLEX PARTIAL SEIZURES; FDG-PET; HYPOMETABOLISM; EEG; LOBECTOMY; MRI;
Keywords:
statistical parametric mapping; glucose metabolism; positron emission tomography; epilepsy; temporal lobe;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Van Bogaert, P Free Univ Brussels, Hop Erasme, PET Biomed Cyclotron Unit, 808 Route Lennik, B-1000 Brussels, Belgium Free Univ Brussels 808 Route Lennik Brussels Belgium B-1000
Citazione:
P. Van Bogaert et al., "Statistical parametric mapping of regional glucose metabolism in mesial temporal lobe epilepsy", NEUROIMAGE, 12(2), 2000, pp. 129-138

Abstract

We investigated statistical parametric mapping (SPM) use for positron emission tomography (PET) with [F-18]fluorodeoxyglucose (FDG) data analysis in mesial temporal lobe epilepsy. The study involved 14 patients with temporallobe epilepsy ultimately treated by anterior temporal lobectomy. Surgical outcome in terms of seizure control was favorable in 12 patients. Two different SPM approaches were designed to analyze each FDG-PET scan: a direct comparison with a control group (n = 27) and a search for significant interhemispheric asymmetry considering the asymmetry existing in the control group. Statistical inference was performed, first, without correction for multiple comparisons (making the hypothesis of temporal hypometabolism) and, second, after correction for multiple comparisons. Search for temporal interhemispheric asymmetry under the hypothesis of temporal hypometabolism was the most reliable SPM approach: hypometabolism was identified on the side chosen for resection in most cases (sensitivity, 71%; specificity, 100%) and waspredictive of favorable postsurgical outcome in 90% of the patients, Therewas no false-positive result within the control group using this approach. After correction for multiple comparisons, SPM also identified in some patients temporal hypermetabolic areas as well as extratemporal cortical and subcortical hypometabolic areas on the side of resection but also on the contralateral side. In a further step, SPM was used for a group analysis of patients with favorable outcome after reversing scans when needed to set an identical lateralization in all patients. This analysis identified multiple ipsilateral temporal and extratemporal hypometabolic regions; when temporalmetabolic changes were specifically assessed, the contralateral mesiotemporal region was found hypermetabolic, possibly as a manifestation of compensatory mechanisms in the presence of a unilateral epileptogenic lesion. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:58:42