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Titolo:
Age-related decline in central serotonin transporter availability with [I-123]beta-CIT SPECT
Autore:
van Dyck, CH; Malison, RT; Seibyl, JP; Laruelle, M; Klumpp, H; Zoghbi, SS; Baldwin, RM; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA VA Connecticut Healthcare Syst, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Diagnost Radiol, New Haven, CT 06520 USA Columbia Univ, New York State Psychiat Inst, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 4, volume: 21, anno: 2000,
pagine: 497 - 501
SICI:
0197-4580(200007/08)21:4<497:ADICST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; 5-HYDROXYTRYPTAMINE-SENSITIVE IMIPRAMINE BINDING; I-123 BETA-CIT; HUMAN-BRAIN; UPTAKE SITES; PROTEIN NATURE; RAT-BRAIN; IN-VIVO; DOPAMINE; LOCALIZATION;
Keywords:
aging; serotonin transporter; [I-123]beta-CIT; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: van Dyck, CH Yale Univ, Sch Med, Dept Psychiat, 333 Cedar St, New Haven, CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 n, CT 06520 USA
Citazione:
C.H. van Dyck et al., "Age-related decline in central serotonin transporter availability with [I-123]beta-CIT SPECT", NEUROBIOL A, 21(4), 2000, pp. 497-501

Abstract

Postmortem studies have provided limited and conflicting data regarding aging effects on the central serotonin transporter (SERT). The present study investigated the effect of age on SERT availability in the human brainstem and diencephalon with single photon emission computed tomography (SPECT) using the ligand [I-123]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([I-123]beta-CIT). Healthy control subjects (n = 126) who ranged in age from 18to 88 were injected with 6.0 +/- 0.8 (mean +/- SD) mCi [I-123]beta-CIT andimaged 23.1 +/- 1.9 h later under equilibrium conditions. A ratio of specific to nondisplaceable brain uptake (i.e., V-3" = [brainstem-diencephalon-occipital]/occipital), a measure proportional to the binding potential (B-max/K-D), was derived. SERT availability (V-3") showed a significant inverse correlation with age (r = -0.40, P < 0.0001). Linear regression analysis revealed that V-3" declined by 29.5% over the age range 18 to 88, or approximately 4.2% per decade. These results demonstrate reductions in the availability of central SERT binding sites with age in living human subjects. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:34:19