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Titolo:
Genome-wide, large-scale production of mutant mice by ENU mutagenesis
Autore:
de Angelis, MH; Flaswinkel, H; Fuchs, H; Rathkolb, B; Soewarto, D; Marschall, S; Heffner, S; Pargent, W; Wuensch, K; Jung, M; Reis, A; Richter, T; Alessandrini, F; Jakob, T; Fuchs, E; Kolb, H; Kremmer, E; Schaeble, K; Rollinski, B; Roscher, A; Peters, C; Meitinger, T; Strom, T; Steckler, T; Holsboer, F; Klopstock, T; Gekeler, F; Schindewolf, C; Jung, T; Avraham, K; Behrendt, H; Ring, J; Zimmer, A; Schughart, K; Pfeffer, K; Wolf, E; Balling, R;
Indirizzi:
GSF, Res Ctr Environm & Hlth, Inst Expt Genet, Neuherberg, Germany GSF Neuherberg Germany onm & Hlth, Inst Expt Genet, Neuherberg, Germany GSF, Res Ctr Environm & Hlth, Inst Pathol, Neuherberg, Germany GSF Neuherberg Germany nvironm & Hlth, Inst Pathol, Neuherberg, Germany GSF, Res Ctr Environm & Hlth, Inst Immunol, Neuherberg, Germany GSF Neuherberg Germany vironm & Hlth, Inst Immunol, Neuherberg, Germany GSF, Res Ctr Environm & Hlth, Inst Mammalian Genet, Neuherberg, Germany GSF Neuherberg Germany Hlth, Inst Mammalian Genet, Neuherberg, Germany Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Munich, Germany Tech Univ Munich Munich Germany icrobiol Immunol & Hyg, Munich, Germany Univ Munich, Gene Ctr, Inst Mol Anim Breeding, Munich, Germany Univ Munich Munich Germany Ctr, Inst Mol Anim Breeding, Munich, Germany Ingenium Pharmaceut AG, Martinsried, Germany Ingenium Pharmaceut AG Martinsried Germany eut AG, Martinsried, Germany Max Delbrueck Ctr, Mol Genet & Mikrosatellitenzentrum, Berlin, Germany MaxDelbrueck Ctr Berlin Germany ikrosatellitenzentrum, Berlin, Germany GSF, TUM, Div Environm Dermatol & Allergol, Munich, Germany GSF Munich Germany M, Div Environm Dermatol & Allergol, Munich, Germany Clin Harlaching, Inst Clin Chem, Munich, Germany Clin Harlaching Munich Germany laching, Inst Clin Chem, Munich, Germany Dr Von Haunerschen Kinderspital, Kinderklin, Abt Klin Chem Biochem & Stoffwechsel, Munich, Germany Dr Von Haunerschen Kinderspital Munich Germany wechsel, Munich, Germany Dr Von Haunerschen Kinderspital, Kinderpoliklin, Munich, Germany Dr Von Haunerschen Kinderspital Munich Germany oliklin, Munich, Germany Univ Klin Freiburg, Freiburg, Germany Univ Klin Freiburg Freiburg Germany iv Klin Freiburg, Freiburg, Germany Univ Munich, Klinikum Grosshadern, Dept Neurobiol, Munich, Germany Univ Munich Munich Germany Grosshadern, Dept Neurobiol, Munich, Germany Univ Munich, Kinderklin, Abt Med Genet, Munich, Germany Univ Munich Munich Germany , Kinderklin, Abt Med Genet, Munich, Germany Max Planck Inst Psychiat, D-8000 Munich, Germany Max Planck Inst PsychiatMunich Germany D-8000 t, D-8000 Munich, Germany Bundesamt Strahlenschutz, Inst Strahlenhyg, Oberschleissheim, Germany Bundesamt Strahlenschutz Oberschleissheim Germany schleissheim, Germany Tel Aviv Univ, Sackler Sch Med, Dept Human Genet, Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel h Med, Dept Human Genet, Tel Aviv, Israel NIMH, Genet Lab, Bethesda, MD USA NIMH Bethesda MD USANIMH, Genet Lab, Bethesda, MD USA Transgene SA, Strasbourg, France Transgene SA Strasbourg FranceTransgene SA, Strasbourg, France
Titolo Testata:
NATURE GENETICS
fascicolo: 4, volume: 25, anno: 2000,
pagine: 444 - 447
SICI:
1061-4036(200008)25:4<444:GLPOMM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE; SPERMATOZOA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: de Angelis, MH GSF, Res Ctr Environm & Hlth, Inst Expt Genet, Neuherberg, Germany GSF Neuherberg Germany t Expt Genet, Neuherberg, Germany
Citazione:
M.H. de Angelis et al., "Genome-wide, large-scale production of mutant mice by ENU mutagenesis", NAT GENET, 25(4), 2000, pp. 444-447

Abstract

In the post-genome era, the mouse will have a major role as a model systemfor functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a systematic, genome-wide, mutagenesis screen in mice. As part of the German Human Genome Project, we have undertaken a large-scale ENU-mutagenesis screen for dominant mutations and a limited screen for recessive mutations'. In screening over 14,000 mice for a large number of clinically relevant parameters, we recovered 182 mouse mutants for a variety of phenotypes. In addition, 247variant mouse mutants are currently in genetic confirmation testing and will result in additional new mutant lines. This mutagenesis screen, along with the screen described in the accompanying paper(2), leads to a significant increase in the number of mouse models(3) available to the scientific community. Our mutant lines are freely accessible to non-commercial users (forinformation, see http://www.gsf.de/ieg/groups/enu-mouse.html).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:26:34