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Titolo:
Mesp2 initiates somite segmentation through the Notch signalling pathway
Autore:
Takahashi, Y; Koizumi, K; Takagi, A; Kitajima, S; Inoue, T; Koseki, H; Saga, Y;
Indirizzi:
Natl Inst Hlth Sci, Cellular & Mol Toxicol Div, Setagaya Ku, Tokyo, Japan Natl Inst Hlth Sci Tokyo Japan l Toxicol Div, Setagaya Ku, Tokyo, Japan Chiba Univ, Sch Med, Dept Dev Biol, Chuo Ku, Chiba, Japan Chiba Univ Chiba Japan v, Sch Med, Dept Dev Biol, Chuo Ku, Chiba, Japan
Titolo Testata:
NATURE GENETICS
fascicolo: 4, volume: 25, anno: 2000,
pagine: 390 - 396
SICI:
1061-4036(200008)25:4<390:MISSTT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARAXIAL MESODERM; DELTA-HOMOLOG; XENOPUS EMBRYOS; LUNATIC FRINGE; MOUSE GENE; EXPRESSION; DROSOPHILA; DII1; MICE; PRESENILIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Koseki, H Natl Inst Hlth Sci, Cellular & Mol Toxicol Div, Setagaya Ku, Tokyo, Japan Natl Inst Hlth Sci Tokyo Japan Div, Setagaya Ku, Tokyo, Japan
Citazione:
Y. Takahashi et al., "Mesp2 initiates somite segmentation through the Notch signalling pathway", NAT GENET, 25(4), 2000, pp. 390-396

Abstract

The Notch-signalling pathway is important in establishing metameric pattern during somitogenesis. In mice, the lack of either of two molecules involved in the Notch-signalling pathway. Mesp2 or presenilin-1 (Ps1), results incontrasting phenotypes: caudalized versus rostralized vertebra. Here we adopt a genetic approach to analyse the molecular mechanism underlying the establishment of rostro-caudal polarity in somites. By focusing on the fact that expression of a Notch ligand, DII1, is important for prefiguring somiteidentity, we found that Mesp2 initiates establishment of rostro-caudal polarity by controlling two Notch-signalling pathways. Initially, Mesp2 activates a Ps1-independent Notch-signalling cascade to suppress DII1 expression and specify the rostral half of the somite. Ps1-mediated Notch-signalling is required to induce DII1 expression in the caudal half of the somite. Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate DII1 expression, resulting in the establishment of the rostro-caudal polarity of somites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:53:17