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Titolo:
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Autore:
Nader, K; Schafe, GE; Le Doux, JE;
Indirizzi:
NYU, Ctr Neural Sci, WM Keck Fdn, Neurobiol Lab, New York, NY 10003 USA NYU New York NY USA 10003 Keck Fdn, Neurobiol Lab, New York, NY 10003 USA
Titolo Testata:
NATURE
fascicolo: 6797, volume: 406, anno: 2000,
pagine: 722 - 726
SICI:
0028-0836(20000817)406:6797<722:FMRPSI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING PROTEIN; LONG-TERM-MEMORY; CONSOLIDATION; PHASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Nader, K NYU, Ctr Neural Sci, WM Keck Fdn, Neurobiol Lab, New York, NY 10003 USA NYU New York NY USA 10003 Neurobiol Lab, New York, NY 10003 USA
Citazione:
K. Nader et al., "Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval", NATURE, 406(6797), 2000, pp. 722-726

Abstract

'New' memories are initially labile and sensitive to disruption before being consolidated into stable long-term memories(1-5). Much evidence indicates that this consolidation involves the synthesis of new proteins in neurons(6-9). The lateral and basal nuclei of the amygdala (LBA) are believed to be a site of memory storage in fear learning(10). Infusion of the protein synthesis inhibitor anisomycin into the LBA shortly after training prevents consolidation of fear memories(11). Here we show that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning. The same treatment with anisomycin, in the absence ofmemory reactivation, left memory intact. Consistent with a time-limited role for protein synthesis production in consolidation, delay of the infusionuntil six hours after memory reactivation produced no amnesia. Our data show that consolidated fear memories, when reactivated, return to a labile state that requires de novo protein synthesis for reconsolidation. These findings are not predicted by traditional theories of memory consolidation.

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Documento generato il 07/07/20 alle ore 12:44:16