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Titolo:
A retinoic acid synthesizing enzyme in ventral retina and telencephalon ofthe embryonic mouse
Autore:
Li, HX; Wagner, E; McCaffery, P; Smith, D; Andreadis, A; Drager, UC;
Indirizzi:
Eunice Kennedy Shriver Ctr Mental Retardat Inc, Waltham, MA 02452 USA Eunice Kennedy Shriver Ctr Mental Retardat Inc Waltham MA USA 02452 2 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Neurol, Boston, MA 02115 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 95, anno: 2000,
pagine: 283 - 289
SICI:
0925-4773(200007)95:1-2<283:ARASEI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDEHYDE DEHYDROGENASE GENE; HOMEOBOX GENE; EXPRESSION; DIFFERENTIATION; IDENTIFICATION; LOCALIZATION; VERTEBRATE; SYSTEM;
Keywords:
retinoic acid; ventral retina; optic stalk; lens; eyelids; lateral ganglionic eminence; septum; piriform cortex; olfactory organ; lens placode; olfactory placode; retinaldehyde dehydrogenase; RALDH1; RALDH2; RALDH3; ALDH6; mouse embryo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Drager, UC Eunice Kennedy Shriver Ctr Mental Retardat Inc, Waltham, MA 02452 USA Eunice Kennedy Shriver Ctr Mental Retardat Inc Waltham MA USA 02452
Citazione:
H.X. Li et al., "A retinoic acid synthesizing enzyme in ventral retina and telencephalon ofthe embryonic mouse", MECH DEVEL, 95(1-2), 2000, pp. 283-289

Abstract

Most retinoic acid (RA) in the embryonic mouse is generated by three retinaldehyde dehydrogenases (RALDHs). RALDH1 (also called E1, AHD2 or ALDH1) isexpressed in the dorsal retina, and RALDH2 (V2, ALDH11) generates most RA in the embryonic trunk. The third one, RALDH3 (V1), synthesizes the bulk ofRA in the head of the early embryo. We show here that RALDH3 is a mouse homologue to ALDH6, an aldehyde dehydrogenase cloned from adult human salivary gland (Hsu, L.C., Chang, W.-C., Hiraoka, L., Hsien, C.-L., 1994. Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6. Genomics 24, 333-341), which was recently reported to act as a RALDH (Yoshida, A., Rzhetsky, A., Hsu, L.C., Chang, C., 1998. Human aldehyde dehydrogenase gene family. Eur. J. Biochem. 251, 549-557). RALDH3 expression begins in the surface ectoderm over the optic recess. In rapidly changing expression patterns it labels the appearance of several ectodermal structures: it marks the formation of the lensand the olfactory organ from ectodermal placodes, and it delineates the beginning eyelid field. Within the optic vesicle, RALDH3 is expressed in the ventral retina and the dorsal pigment epithelium. In the telencephalon, RALDH3 is expressed at high levels in the lateral part of the ganglionic eminence. From here it extends via the piriform cortex into the lower part of the septum. Of the three RALDHs, RALDH3 shows the strongest predilection for epithelia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:01:34