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Titolo:
Erectile dysfunction in patients with spina bifida is a treatable condition
Autore:
Palmer, JS; Kaplan, WE; Firlit, CF;
Indirizzi:
Northwestern Univ, Sch Med, Childrens Mem Hosp, Div Urol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 p, Div Urol, Chicago, IL 60611 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 3, volume: 164, anno: 2000,
parte:, 2
pagine: 958 - 961
SICI:
0022-5347(200009)164:3<958:EDIPWS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Keywords:
spinal dysraphism; meningomyelocele; impotence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Palmer, JS Northwestern Univ, Sch Med, Childrens Mem Hosp, Div Urol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 , Chicago, IL 60611 USA
Citazione:
J.S. Palmer et al., "Erectile dysfunction in patients with spina bifida is a treatable condition", J UROL, 164(3), 2000, pp. 958-961

Abstract

Purpose: Now that individuals with spina bifida live well into adulthood erectile dysfunction has become a recognized associated medical disorder. Toour knowledge no study has dealt specifically with treatment of erectile dysfunction in men with spina bifida. Therefore, we conducted a prospective,blinded, randomized, placebo controlled, dose escalation, crossover study to determine the ability to treat erectile dysfunction in men with spina bifida with sildenafil citrate. Materials and Methods: Erectile dysfunction was diagnosed in 15 men 19 to 35 years old with spina bifida who were assigned to take 4 sets of tablets,5 tablets per set, in a random order. All patients took 25 and 50 rug. sildenafil and 2 identical looking sets of corresponding placebos I hour before planned sexual activity. Efficacy was assessed by the effect of treatmentcompared to baseline, that is before treatment, on rating of erections (scored from 0 to 10), duration of erections, frequency of erections based on response to question 1 (scored from 0 to 5) of the International Index of Erectile Function and confidence to obtain an erection based on response to question 15 (scored from 1 to 5) of the International Index of Erectile Function. Results: Improved erectile function was reported while on sildenafil by 12(80%) men compared to baseline and placebos. There was a significant dose dependent improvement of erectile function with both 25 and 50 mg. sildenafil compared to baseline (p < 0.05), as mean erectile score increased by 50%and 88%, mean duration of erections increased by 192% and 266%, mean frequency of erections increased by 61% and 96%, and mean level of confidence increased by 33% and 63%, respectively. Furthermore, 50 mg. sildenafil provided greater improvement in all 4 parameters compared to 25 mg. The placebo results were not significantly different compared to baseline for any of theparameters. Conclusions: Erectile dysfunction in patients with spina bifida is a medically treatable condition. Sildenafil is effective in this patient population and improves level of sexual confidence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:56:28