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Titolo:
Ligand-presenting assembly: a method for C- and N-terminal antigen presentation
Autore:
Holm, A; Jorgensen, RM; Ostergaard, S; Theisen, M;
Indirizzi:
Royal Vet & Agr Univ, Dept Chem, Med Biotechnol Res Ctr, DK-1871 Frederiksberg C, Denmark Royal Vet & Agr Univ Frederiksberg Denmark C 71 Frederiksberg C, Denmark Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark Novo Nordisk AS Bagsvaerd Denmark DK-2880 AS, DK-2880 Bagsvaerd, Denmark Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark StatensSerum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark
Titolo Testata:
JOURNAL OF PEPTIDE RESEARCH
fascicolo: 2, volume: 56, anno: 2000,
pagine: 105 - 113
SICI:
1397-002X(200008)56:2<105:LAAMFC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPEPTIDE DENDRIMERS; PEPTIDES;
Keywords:
B-cell epitope; Borrelia afzelii; Borrelia burgdorferi; Borrelia garinii; dendritic; ligand-presenting assembly; LPA; Lyme borreliosis; MAP; SPPS; T-cell epitope;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, A Royal Vet & Agr Univ, Dept Chem, Med Biotechnol Res Ctr, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark Royal Vet & Agr Univ Thorvaldsensvej 40 Frederiksberg Denmark C k
Citazione:
A. Holm et al., "Ligand-presenting assembly: a method for C- and N-terminal antigen presentation", J PEPT RES, 56(2), 2000, pp. 105-113

Abstract

Achiral dicarboxylic acids were coupled with 2 eq. of the free or-amino groups of two fully side-chain protected peptide chains while these were still attached to a synthesis resin. Cleavage from the resin with simultaneous side-chain deprotection afforded two assembled peptide chains with free C-terminals. Suitable functionalization of the achiral dicarboxylic acid alternatively permited continued peptide synthesis in a C to N orientation leading to a final peptide assembly which, after cleavage from the resin, may have multiple N to C and C to N presentation of one or more epitopes.

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Documento generato il 29/11/20 alle ore 18:33:24