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Titolo:
Dopamine transporter binding in Gilles de la Tourette syndrome
Autore:
Muller-Vahl, KR; Berding, G; Brucke, T; Kolbe, H; Meyer, GJ; Hundeshagen, H; Dengler, R; Knapp, WH; Emrich, HM;
Indirizzi:
Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 apy, D-30623 Hannover, Germany Hannover Med Sch, Dept Neurol, D-30623 Hannover, Germany Hannover Med SchHannover Germany D-30623 rol, D-30623 Hannover, Germany Hannover Med Sch, Dept Nucl Med, D-30623 Hannover, Germany Hannover Med Sch Hannover Germany D-30623 Med, D-30623 Hannover, Germany Univ Vienna, Neurol Clin, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Neurol Clin, Vienna, Austria Univ Vienna, Clin Nucl Med, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Clin Nucl Med, Vienna, Austria
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 7, volume: 247, anno: 2000,
pagine: 514 - 520
SICI:
0340-5354(200007)247:7<514:DTBIGD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 BETA-CIT; SELF-INJURIOUS-BEHAVIOR; SEROTONIN TRANSPORTERS; REUPTAKE SITES; SPECT; BRAIN; DISEASE; IODINE-123-BETA-CIT; DISORDER; SEVERITY;
Keywords:
dopamine transporter; 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane single photon emission computed tomography; Gilles de la Tourette syndrome; tics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Muller-Vahl, KR Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, CarlNeuberg Str 1, D-30623 Hannover, Germany Hannover Med Sch Carl Neuberg Str1 Hannover Germany D-30623
Citazione:
K.R. Muller-Vahl et al., "Dopamine transporter binding in Gilles de la Tourette syndrome", J NEUROL, 247(7), 2000, pp. 514-520

Abstract

Preliminary studies in patients with Gilles de la Tourette syndrome (TS) provided evidence of presynaptic dopaminergic dysfunction, demonstrating increased reuptake sites. Therefore we investigated striatal dopamine transporter binding in 12 TS patients and 9 control subjects using single photon emission computed tomography and I-123-labeled 2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane. In TS patients we found significantly higher relative striatal activity ratios (mean +/-SD 12.33+/-3.58) than in controls (9.36+/-1.35, P < 0.05). Only five patients, however, showed striatum/occipital cortex ratios more than 2 SD above the normal means. Seven patients had activity ratios within the average ratio of the control group plus 2 SD. Regarding the relationship between clinical parameters and striatum/occipital cortex ratios, we found an association between binding ratios and "self-injurious behavior" and "lack of impulse control. " This study corroborates previousdata suggesting an involvement of the dopaminergic system in TS pathology. Our results demonstrate that an increase in dopamine transporter capacity is a possible but not a necessary alteration, and which appears more likelywhen self-injurious behavior and lack of impulse control are associated.

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Documento generato il 17/09/19 alle ore 23:17:40