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Titolo:
Use of [I-123]-BMIPP myocardial scintigraphy for the clinical evaluation of a fatty-acid metabolism disorder of the right ventricle in chronic respiratory and pulmonary vascular disease
Autore:
Matsushita, T; Ikeda, S; Miyahara, Y; Yakabe, K; Yamaguchi, K; Furukawa, K; Iwasaki, T; Shikuwa, M; Fukui, J; Kohno, S;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 rnal Med 2, Nagasaki 8528501, Japan
Titolo Testata:
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
fascicolo: 3, volume: 28, anno: 2000,
pagine: 111 - 123
SICI:
0300-0605(200005/06)28:3<111:UO[MSF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERTROPHIC CARDIOMYOPATHY; COMPUTED-TOMOGRAPHY; TL-201; BMIPP; ACCUMULATION; PERFUSION; OVERLOAD; ANALOG; HEART; SPECT;
Keywords:
[I-123]-BMIPP myocardial scintigraphy; right ventricle pressure overload; fatty-acid metabolism; chronic respiratory disease; pulmonary vascular disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Matsushita, T Nagasaki Univ, Sch Med, Dept Internal Med 2, 1-7-1 Sakamoto,Nagasaki 8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 , Japan
Citazione:
T. Matsushita et al., "Use of [I-123]-BMIPP myocardial scintigraphy for the clinical evaluation of a fatty-acid metabolism disorder of the right ventricle in chronic respiratory and pulmonary vascular disease", J INT MED R, 28(3), 2000, pp. 111-123

Abstract

The objective of this study was to evaluate whether or not right ventricle(RV) uptake of iodine-123-labelled-beta-methyliodo-phenylpentadecanoic acid ([I-123]-BMIPP) correlated with the degree of right ventricular pressure overload (RVPO). Myocardial scintigraphy of [I-123]-BMIPP and thallium-201 (Tl-201) was performed on 46 patients with RVPO. We determined the right ventricle (RV)/left ventricle (LV) ratio = (radioactivities of RV)/(radioactivities of LV), and the RV metabolic index (RVMI) = (RV/LV ratio of [I-123]-BMIPP)/(RV/LV ratio of Tl-201). We also evaluated the correlation between RVMI and mean pulmonary arterial pressure (mPAP), and between RVMI and totalpulmonary resistance (TPR). Significant correlations were found between the RV/LV ratio of [I-123]-BMIPP and mPAP and between the RV/LV ratio of [I-123]-BMIPP and TPR. In addition, a significant negative correlation was observed between RVMI and mPAP and between RVMI and TPR. RVMI declined as RVPO increased, suggesting the presence of a fatty-acid metabolism disorder of the RV. Moreover, [I-123]-BMIPP myocardial scintigraphy could be useful for evaluating a disorder of the fatty-acid metabolism of the RV with RVPO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:43:38