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Titolo:
Cross-resistance to alpha-cypermethrin after xanthotoxin ingestion in Helicoverpa zea (Lepidoptera : Noctuidae)
Autore:
Li, XC; Zangerl, AR; Schuler, MA; Berenbaum, MR;
Indirizzi:
Univ Illinois, Dept Entomol, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Dept Entomol, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF ECONOMIC ENTOMOLOGY
fascicolo: 1, volume: 93, anno: 2000,
pagine: 18 - 25
SICI:
0022-0493(200002)93:1<18:CTAAXI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLACK SWALLOWTAIL; DRUG METHOXSALEN; HELIOTHIS-ZEA; CYTOCHROME-P-450; INSECTICIDES; FURANOCOUMARINS; INACTIVATION; FIELD;
Keywords:
Helicoverpa zea; alpha-cypermethrin; xanthotoxin; cross-resistance; cytochrome P450 monooxygenases; synergism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Li, XC Nanjing Agr Univ, Dept Plant Protect, Nanjing 210095, Peoples R China Nanjing Agr Univ Nanjing Peoples R China 210095 , Peoples R China
Citazione:
X.C. Li et al., "Cross-resistance to alpha-cypermethrin after xanthotoxin ingestion in Helicoverpa zea (Lepidoptera : Noctuidae)", J ECON ENT, 93(1), 2000, pp. 18-25

Abstract

Cytochrome P450 monooxygenases (P450) are membrane-bound hemoproteins thatplay important roles in conferring protection against both naturally occurring phytochemicals and synthetic organic insecticides. Despite the potential for common modes of detoxification, cross-resistance between phytochemicals and synthetic organic insecticides has rarely been documented. In this study, we examined the responses of a susceptible strain of corn earworm, Helicoverpa zea (Boddie), a polyphagous noctuid, to exposure by an allelochemical infrequently encountered in its host plants and by an insecticide widely used for control purposes. Within a single generation, survivors of xanthotoxin exposure displayed higher levels of tolerance to alpha-cypermethrin than did unexposed control larvae. The F-1 offspring of xanthotoxin-exposed survivors also displayed higher alpha-cypermethrin tolerance than did offspring of unexposed control larvae, suggesting that increased alpha-cypermethrin tolerance after xanthotoxin exposure represents, at least in part, heritable resistance. Administration of piperonyl butoxide, a P450 synergist, demonstrated that resistance to both xanthotoxin and alpha-cypermethrin is P450-mediated. alpha-Cypermethrin-exposed survivors, however, failed to show superior growth on xanthotoxin diets. Assays with control larvae, larvae induced, by both xanthotoxin and alpha-cypermethrin, and survivors of LD50 doses of both compounds indicated that H. tea midgut P450s are capable ofmetabolizing both xanthotoxin and alpha-cypermethrin. Metabolism of each compound is significantly inhibited by the presence of the other compound, suggesting that at least one form of P450 in H. sea midguts degrades both compounds and may constitute the biochemical basis for possible cross-resistance. Compared with control larvae, xanthotoxin- and alpha-cypermethrin-induced larvae displayed 2- to 4-fold higher P450-mediated metabolism of both compounds. However, xanthotoxin- and alpha-cypermethrin-exposed survivors exhibited much higher ( 2.5- to 11-fold) metabolism of both compounds than did the induced larvae. The metabolism results, like the bioassay results, are consistent with the interpretation that increased alpha-cypermethrin tolerance after xanthotoxin exposure is attributable mainly to heritable resistance.

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Documento generato il 30/11/20 alle ore 05:44:25