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Titolo:
Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy
Autore:
Watkins, CC; Sawa, A; Jaffrey, S; Blackshaw, S; Barrow, RK; Snyder, SH; Ferris, CD;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ Baltimore MD USA 21205 Mol Sci, Baltimore, MD 21205USA Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 av Sci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 nterol, Baltimore, MD 21205 USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 3, volume: 106, anno: 2000,
pagine: 373 - 384
SICI:
0021-9738(200008)106:3<373:IRNNOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRRITABLE-BOWEL-SYNDROME; ENTERIC NERVOUS-SYSTEM; RAT GASTRIC FUNDUS; PYLORIC MOTILITY; MYENTERIC PLEXUS; SMALL-INTESTINE; RNA DIVERSITY; GENE NOS1; MELLITUS; HYPERGLYCEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Ferris, CD Vanderbilt Univ, Med Ctr, Dept Med, Div Gastroenterol, C-2104 Med Ctr N, Nashville, TN 37232 USA Vanderbilt Univ C-2104 Med Ctr N Nashville TN USA 37232 232 USA
Citazione:
C.C. Watkins et al., "Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy", J CLIN INV, 106(3), 2000, pp. 373-384

Abstract

Gastrointestinal dysfunction is common in diabetic patients. In genetic (nonobese diabetic) and toxin-elicited (streptozotocin) models of diabetes inmice, we demonstrate defects in gastric emptying and nonadrenergic, noncholinergic relaxation of pyloric muscle, which resemble defects in mice harboring a deletion of the neuronal nitric oxide synthase gene (nNOS). The diabetic mice manifest pronounced reduction ill pyloric nNOS protein and mRNA, The decline of nNOS in diabetic mice does not result from loss of myentericneurons. nNOS expression and pyloric function are restored to normal levels by insulin treatment. Thus diabetic gastropathy in mice reflects an insulin-sensitive reversible loss of nNOS. In diabetic animals, delayed gastric emptying can be reversed with a phosphodiesterase inhibitor, sildenafil, These findings have implications for novel therapeutic approaches and may clarify the etiology of diabetic gastropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:27:36