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Titolo:
G proteins as a biochemical tool for diagnosis and monitoring treatments of mental disorders
Autore:
Schreiber, G; Avissar, S;
Indirizzi:
Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Ben Gurion Univ Negev, Fac Hlth Sci, Dept Psychiat, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
, volume: 2, anno: 2000, supplemento:, S
pagine: 86 - 91
SICI:
1565-1088(200007)2:<86:GPAABT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; RECEPTOR-MEDIATED ACTIVATION; BETA-ADRENERGIC-RECEPTOR; GTP-BINDING PROTEIN; COUPLED G-PROTEINS; MONONUCLEAR LEUKOCYTES; ALPHA-SUBUNIT; SCHIZOPHRENIC BRAIN; DEPRESSED-PATIENTS; ADENYLATE-CYCLASE;
Keywords:
G proteins; depression; mania; schizophrenia; mononuclear leukocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Avissar, S Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Pharmacol, POB 653, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev POB 653 Beer Sheva Israel IL-84105 srael
Citazione:
G. Schreiber e S. Avissar, "G proteins as a biochemical tool for diagnosis and monitoring treatments of mental disorders", ISR MED ASS, 2, 2000, pp. 86-91

Abstract

There is a significant gap between advances in medication for mental disorders and the present static situation of diagnosis and monitoring treatments of these disorders. Heterotrimeric G proteins play a pivotal role in post-receptor information transduction. These proteins were previously implicated by us in the biochemical mechanism underlying lithium action, and in thepathophysiology of mood disorders. We aimed at quantitatively and functionally evaluating G proteins in patients with, major mental disorders in an attempt to unravel a differential pattern of G protein measures characterizing each disorder. We undertook G protein functional measurements coupled tobeta-adrenergic, muscarinic or dopamine receptors through bacterial toxin-sensitive, agonist-enhanced [H-3]-Gpp(NH)p binding capacity, substantiated by quantitative measures of G alpha(s), G alpha(i) and G beta subunit proteins through immunoblot analysis using polyclonal anti-G subunit antibodies in mononuclear leukocytes obtained from patients with major mental disorders in comparison with healthy volunteers. A differential pattern of receptor-coupled G protein function and of their immunoreactive levels was detectedin mononuclear leukocytes of patients for the following mental disorders: mania, depression, schizophrenia, and panic. Normalization of altered G protein measures in mood-disordered patients occurred under specific treatments. As state-dependent markers, G protein measures can potentially be used as an aid in both the biochemical diagnosis of mental disorders and in the biochemical monitoring of the response to a specific treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:17:19