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Titolo:
Relative biological effectiveness for cell-killing effect on various humancell lines irradiated with heavy-ion medical accelerator in CHIBA (HIMAC) carbon-ion beams
Autore:
Suzuki, M; Kase, Y; Yamaguchi, H; Kanai, T; Ando, K;
Indirizzi:
Natl Inst Radiol Sci, Div Accelerator Phys & Engn, Chiba 260, Japan Natl Inst Radiol Sci Chiba Japan 260 rator Phys & Engn, Chiba 260, Japan Natl Inst Radiol Sci, Int Space Radiat Lab, Inage Ku, Chiba 263, Japan Natl Inst Radiol Sci Chiba Japan 263 iat Lab, Inage Ku, Chiba 263, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 1, volume: 48, anno: 2000,
pagine: 241 - 250
SICI:
0360-3016(20000801)48:1<241:RBEFCE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; CHINESE-HAMSTER CELLS; HUMAN-TUMOR-CELLS; IN-SITU HYBRIDIZATION; LOW-ENERGY PROTONS; MAMMALIAN-CELLS; CHROMOSOME-ABERRATIONS; IONIZING-RADIATION; V79 CELLS; GEL-ELECTROPHORESIS;
Keywords:
human cell lines; HIMAC; carbon-ion beams; linear energy transfer (LET); cross section;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, M Columbia Univ Coll Phys & Surg, Dept Radiat Oncol, Ctr Radiol Res, 630 W 168th St,VC11-233, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St,VC11-233 New York NY USA 10032
Citazione:
M. Suzuki et al., "Relative biological effectiveness for cell-killing effect on various humancell lines irradiated with heavy-ion medical accelerator in CHIBA (HIMAC) carbon-ion beams", INT J RAD O, 48(1), 2000, pp. 241-250

Abstract

Purpose: To clarify the relative biological effectiveness (RBE) values of various human cell lines for carbon-ion beams with 2 different linear energy transfer (LET) beams and to investigate the relationship between the cell-killing effect and the biophysical characters, such as the chromosome number and the area of the cell nucleus, using qualitatively different kinds ofradiations. Methods and Materials: Sixteen different human cell lines were irradiated with carbon-ion beams, having 2 different LET values (LETinfinity = 13.3 and approximately 77 keV/mu m), accelerated by the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences in Japan. Cell-killing effect was detected as reproductive cell death using a colony-formation assay. The number of chromosomes was observed in a metaphase spread using the conventional method, The area of the cell nucleus was calculated as an ellipse on photographs using a micrometer,Results: The RBE values calculated by the D-10, which is determined as thedose (Gy) required to reduce the surviving fraction to 10%, relative to X-rays, range from 1.06 to 1.33 for 13-keV/mu m-beam and from 2.00 to 3.01 for approximate 77-keV/mu m-beam irradiation on each cell line, There was a good correlation in the D-10 values of each cell line between X-rays and carbon-ion beams. However, the D-10 values did not clearly depend on either the chromosome number or the area of the cell nuclei. Conclusion: The RBE values for HIMAC carbon-ion beams are consistent with previous reports using carbon-ion beams with the similar LET values, and the cellular radiosensitivity of different cell lines,well correlate among different types of radiation. (C) 2000 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:30:31