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Titolo:
Vasoconstrictive eicosanoid responses to extracorporeal circulation with or without an oxygenator in fetal lambs
Autore:
Kim, WG; Lee, JR; Kim, CS; Choi, JY; Kim, YJ;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 Surg, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Heart Res Inst, Seoul 110744, South Korea SeoulNatl Univ Seoul South Korea 110744 Inst, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Anesthesiol, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 siol, Seoul 110744, South Korea Seoul Natl Univ, Coll Med, Dept Pediat, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 diat, Seoul 110744, South Korea Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea Seoul Natl Univ Hosp Seoul South Korea 110744 Seoul 110744, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
fascicolo: 7, volume: 23, anno: 2000,
pagine: 436 - 440
SICI:
0391-3988(200007)23:7<436:VERTEC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC BYPASS; PLACENTAL DYSFUNCTION; INHIBITION; SURGERY;
Keywords:
fetal cardiac bypass; eicosanoid; prostaglandin; thromboxane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, WG Seoul Natl Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Yeunkun Dong 28,Seoul 110744, South Korea Seoul Natl Univ Yeunkun Dong 28 Seoul South Korea 110744 th Korea
Citazione:
W.G. Kim et al., "Vasoconstrictive eicosanoid responses to extracorporeal circulation with or without an oxygenator in fetal lambs", INT J ARTIF, 23(7), 2000, pp. 436-440

Abstract

Introduction. This study measured levels of vasoconstrictive eicosanoids during ovine fetal cardiac bypass and compared the measurements between two groups: (1) a group in which the placenta functioned as the only source of oxygen supply during the bypass (the placenta group), and (2) a group in which an artificial oxygenator instead of the placenta, was included in the bypass circuit (the oxygenator group). Materials and Methods. A total of 16 fetal lambs were randomly assigned into either the oxygenator group or the placenta group. Following anesthesia,the fetal cardiac bypass procedure was performed. The placenta group used a centrifugal pump as the pumping device without an oxygenator during the bypass. The bypass circuit in the oxygenator group consisted of a roller pump and a membrane oxygenator The fetal cardiac bypass procedure was performed for 30 minutes at normothermia in both groups. For the measurements of thromboxane B-2(TXB2) and prostaglandin E-2(PGE(2)), blood sampels were takenbefore the bypass, at 5 minutes, 15 minutes, and 30 minutes after the start of cardiac bypass, and at 15 minutes after weaning from the bypass. TXB2 and PGE(2) levels were determined by radioimmunoassay with PGE(2)(I-125) and TXB2(I-125) assay systems. Hemodynamic observations and arterial blood gas analyses were done every 10 minutes. Results. The mean arterial pressure and heart rate ranged from 69.8 to 82.6 mmHg and 169 to 182/min during the bypass in the oxygenator group, and from 14.4 to 44.7 mmHg and 64.3 to 75/min in the placenta group. Arterial blood gas analysis showed severe hypercapnia and hypoxemia with acidosis during and after the bypass in the placenta group. Bypass flow rates were maintained at 140.3-164.0 ml/kg/min in the oxygenator group, while flow rates were suboptimal (74.3-97.0 ml/kg/min) in the placenta group. There were no statistically significant differences in PGE(2) concentrations before, during,or after bypass, although the placenta group displayed a tendency to higher measurements during bypass, compared to the oxygenator group. The placenta group also showed higher TXB2 measurements than the oxygenator group during the bypass (p=0.0457). Conclusions. We have demonstrated increase measurements of PGE(2) and TXB2in the placenta group when compared with the oxygenator group in an ovine fetal cardiac bypass model, although the PGE, difference failed to reach statistical significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:48:47