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Titolo:
Taraxacum officinale inhibits tumor necrosis factor-alpha production from rat astrocytes
Autore:
Kim, HM; Shin, HY; Lim, KH; Ryu, ST; Shin, TY; Chae, HJ; Kim, HR; Lyu, YS; An, NH; Lim, KS;
Indirizzi:
Wonkwang Univ, Coll Pharm, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Wonkwang Univ, Dept Won Buddhism, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea Woosuk Univ, Coll Pharm, Wanju 565701, Chonbuk, South Korea Woosuk Univ Wanju Chonbuk South Korea 565701 565701, Chonbuk, South Korea Wonkwang Univ, Sch Dent, Dept Dent Pharmacol, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 3, volume: 22, anno: 2000,
pagine: 519 - 530
SICI:
0892-3973(2000)22:3<519:TOITNF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN-PRESENTING CELLS; ALZHEIMERS-DISEASE; BRAIN; LIPOPOLYSACCHARIDE; EXPRESSION; INTERLEUKIN-1; INDUCTION; INTERFERON; SECRETION; CYTOKINES;
Keywords:
Taraxacum officinale; tumor necrosis factor-alpha; astrocytes; lipopolysaccharide; substance P; interleukin-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM Wonkwang Univ, Coll Pharm, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 onbuk, South Korea
Citazione:
H.M. Kim et al., "Taraxacum officinale inhibits tumor necrosis factor-alpha production from rat astrocytes", IMMUNOPH IM, 22(3), 2000, pp. 519-530

Abstract

Substance P (SP) can stimulate production of tumor necrosis factor-alpha (TNF-alpha) from astrocytes stimulated with lipopolysaccharide (LPS). The objective of the current study was to determine the effect of Taraxacum officinale (TO) on the production of TNF-alpha from primary cultures of rat astrocytes. TO (100 and 1000 mu g/ml) significantly inhibited the TNF-alpha production by astrocytes stimulated with LPS and SP. Interleukin-1 (IL-1) has been shown to elevate TNF-alpha production from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore examined whether IL-1 mediated inhibition of TNF-alpha production from primaryastrocytes by TO. Treatment of TO (100 and 1000 mu g/ml) to astrocytes stimulated with both LPS and SP decreased IL-1 production significantly. Moreover, the production of TNF-alpha by LPS and SP in astrocytes was progressively inhibited with increasing amount of IL-1 neutralizing antibody. Our results suggest that TO may inhibit TNF-alpha production by inhibiting IL-1 production and that TO has an antiinflammatory activity in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:26:57