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Titolo:
Increased HLA-DR homozygosity associated with pre-eclampsia
Autore:
Brunori, ID; Battini, L; Simonelli, M; Clemente, F; Brunori, E; Mariotti, ML; Genazzani, AR;
Indirizzi:
Univ Pisa, S Chiara Hosp, Dept Reprod Med & Child Dev, Div Gynaecol & Obstet, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 Div Gynaecol & Obstet, I-56100 Pisa, Italy Univ Pisa, S Chiara Hosp, Stella Maris Fdn, I-56100 Pisa, Italy Univ PisaPisa Italy I-56100 Hosp, Stella Maris Fdn, I-56100 Pisa, Italy Univ Pisa, S Chiara Hosp, Inst Immunohematol, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 sp, Inst Immunohematol, I-56100 Pisa, Italy
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 8, volume: 15, anno: 2000,
pagine: 1807 - 1812
SICI:
0268-1161(200008)15:8<1807:IHHAWP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; HUMAN-LEUKOCYTE ANTIGEN; IMMUNOLOGICAL ASPECTS; SEVERE PREECLAMPSIA; HUMAN IMPLANTATION; ENDOTHELIAL-CELLS; HUMAN-PLACENTA; DISORDERS; PREGNANCY; HLA-DR4;
Keywords:
histocompatibility; HLA-DR antigens; homozygosity; pre-eclampsia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brunori, ID Lung Arno Simonelli 3, I-56100 Pisa, Italy Lung Arno Simonelli 3 Pisa Italy I-56100 I-56100 Pisa, Italy
Citazione:
I.D. Brunori et al., "Increased HLA-DR homozygosity associated with pre-eclampsia", HUM REPR, 15(8), 2000, pp. 1807-1812

Abstract

It is generally accepted that maternal recognition of paternally derived fetal antigens occurs during normal pregnancy and may be beneficial for implantation and maintenance of gestation, Thus, we have investigated the humanleukocyte class II DR antigens (HLA-DR), whose role in self and non-self recognition is well known, in women with preeclampsia, their partners and incontrol couples. The HLA-DR antigens were tested in 70 pre-eclamptic primigravidae women and their partners and 70 healthy control couples using the serological Terasaki technique, Our results did not show any particular HLA-DR antigen to be correlated with pre-eclampsia, but a statistically significant increase of only one identifiable HLA-DR antigen, which was presumed to express homozygosity at the HLA-DR locus, in the pre-eclamptic women andtheir partners: 67.1 versus 7.9% in the control couples (P < 0.000001). The analysis of HLA-DR compatibility between pre-eclamptic women and their partners showed a statistically highly significant increase of the female-to-male compatibility (P = 0.0003) and a lower but significant male-to-female compatibility in comparison with controls (P = 0.014). From our results, itemerges that HLA-DR homozygosity and reduced antigenic disparity seem to be associated to a major risk for pre-eclampsia, which consequently appears to be a 'couple's disease'.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:09:42