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Titolo:
Differences in the distribution of synemin, paranemin, and plectin in skeletal muscles of wild-type and desmin knock-out mice
Autore:
Carlsson, L; Li, ZL; Paulin, D; Price, MG; Breckler, J; Robson, RM; Wiche, G; Thornell, LE;
Indirizzi:
Umea Univ, Dept Integrat Med Biol, Sect Anat, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Med Biol, Sect Anat, S-90187 Umea, Sweden Natl Inst Working Life, Ctr Musculoskeletal Res, S-90713 Umea, Sweden NatlInst Working Life Umea Sweden S-90713 tal Res, S-90713 Umea, Sweden Univ Paris 07, F-75005 Paris, France Univ Paris 07 Paris France F-75005Univ Paris 07, F-75005 Paris, France Baylor Coll Med, Dept Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ept Cell Biol, Houston, TX 77030 USA San Francisco State Univ, Dept Biol, San Francisco, CA 94132 USA San Francisco State Univ San Francisco CA USA 94132 ancisco, CA 94132 USA Iowa State Univ, Dept Biochem Biophys & Mol Biol, Muscle Biol Grp, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 ol, Muscle Biol Grp, Ames, IA 50011 USA Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 Univ, Dept Anim Sci, Ames, IA 50011 USA Univ Vienna, Inst Biochem & Mol Cell Biol, A-1030 Vienna, Austria Univ Vienna Vienna Austria A-1030 Mol Cell Biol, A-1030 Vienna, Austria
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 1, volume: 114, anno: 2000,
pagine: 39 - 47
SICI:
0948-6143(200007)114:1<39:DITDOS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FILAMENT PROTEIN SYNEMIN; INTERMEDIATE FILAMENTS; MOLECULAR CHARACTERISTICS; NEUROMUSCULAR-JUNCTIONS; MYOTENDINOUS JUNCTIONS; VIMENTIN FILAMENTS; LACKING DESMIN; ROD DOMAIN; CYTOSKELETON; MYOPATHY;
Keywords:
cytoskeleton; desmin knock-out mice; intermediate filament-associated proteins myotendinous junctions; neuromuscular junctions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Carlsson, L Umea Univ, Dept Integrat Med Biol, Sect Anat, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 ect Anat, S-90187 Umea, Sweden
Citazione:
L. Carlsson et al., "Differences in the distribution of synemin, paranemin, and plectin in skeletal muscles of wild-type and desmin knock-out mice", HISTOCHEM C, 114(1), 2000, pp. 39-47

Abstract

Mice lacking the gene encoding fur the intermediate filament protein desmin have a surprisingly normal myofibrillar organization in skeletal muscle fibers, although myopathy develops in highly used muscles. In the present study we examined how synemin, paranemin, and plectin, three key cytoskeletalproteins related to desmin, are organized in normal and desmin knock-out (K/O) mice. We show that in wild-type mice, synemin, paranemin, and plectin were colocalized with desmin in Z-disc-associated striations and at the sarcolemma. All three proteins were also present at the myotendinous junctionsand in the postsynaptic area of motor end-plates. In the desmin K/O mice the distribution of plectin was unaffected, whereas synemin and paranemin were partly affected. The Z-disc-associated striations were in general no longer present in between the myofibrils. In contrast, at the myotendinous andneuromuscular junctions synemin and paranemin were still present. Our study shows that plectin differs from synemin and paranemin in its binding properties to the myofibrillar Z-discs and that the cytoskeleton in junctional areas is particularly complex in its organization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:37:38