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Titolo:
RADIATION-DOSIMETRY OF [F-18] (N-METHYL)BENPERIDOL AS DETERMINED BY WHOLE-BODY PET IMAGING OF PRIMATES
Autore:
MOERLEIN SM; PERLMUTTER JS; CUTLER PD; WELCH MJ;
Indirizzi:
WASHINGTON UNIV,MED CTR,MALLINCKRODT INST RADIOL,SCH MED,510 S KINGSHIGHWAY ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT BIOCHEM & MOL BIOPHYS ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROSURG ST LOUIS MO 63110
Titolo Testata:
Nuclear medicine and biology
fascicolo: 4, volume: 24, anno: 1997,
pagine: 311 - 318
SICI:
0969-8051(1997)24:4<311:RO[(AD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; DOPAMINE-RECEPTOR; BIODISTRIBUTION; BINDING; BRAIN; RADIOPHARMACEUTICALS; INVIVO; SPECT; RADIOLIGAND; D2;
Keywords:
DOSIMETRY; [F-18] (N-METHYL)BENPERIDOL; [F-18] NMB; D2 RECEPTOR LIGANDS; POSITRON EMISSION TOMOGRAPHY; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Moerlein et al., "RADIATION-DOSIMETRY OF [F-18] (N-METHYL)BENPERIDOL AS DETERMINED BY WHOLE-BODY PET IMAGING OF PRIMATES", Nuclear medicine and biology, 24(4), 1997, pp. 311-318

Abstract

Radiation absorbed doses due to IV administration of [F-18](N-methyl)benperidol ([F-18]NMB) were estimated by whole-body PET imaging of nonhuman primates. Time-activity curves were obtained for nine compartments (striatum, eyes, heart, lungs, liver, gallbladder, intestines, kidneys, bladder) by using dynamic PET scans of three different baboons given the radiotracer. These time activity curves were used to calculatethe residence times of radioactivity in these tissues. Human absorbeddose estimates were calculated using the updated MIRDOSE 3 S values and assuming the same biodistribution. Based on an average of three studies, the critical organs were the lower large intestine, gallbladder,and liver, receiving doses of 585, 281, and 210 mrad/mCi, respectively. The brain received a dose of 13 mrad/mCi; other organs received doses between 32-77 mrad/mCi. These results indicate that up to 8.5 mCi of [F-18]NMB can be safely administered to human subjects for PET studies of D2 receptor binding. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:00:27