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Titolo:
The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
Autore:
Xiao, W; Chow, BL; Broomfield, S; Hanna, M;
Indirizzi:
Univ Saskatchewan, Dept Microbiol & Immunol, Saskatoon, SK S7N 5E5, CanadaUniv Saskatchewan Saskatoon SK Canada S7N 5E5 skatoon, SK S7N 5E5, Canada
Titolo Testata:
GENETICS
fascicolo: 4, volume: 155, anno: 2000,
pagine: 1633 - 1641
SICI:
0016-6731(200008)155:4<1633:TSCRGI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-CONJUGATING-ENZYME; CELL NUCLEAR ANTIGEN; YEAST DNA-POLYMERASE; SIMPLE REPETITIVE SEQUENCES; NIJMEGEN BREAKAGE SYNDROME; THYMINE-THYMINE DIMER; ESCHERICHIA-COLI DINB; DOUBLE-STRAND BREAKS; 2 HUMAN HOMOLOGS; XERODERMA-PIGMENTOSUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Xiao, W Univ Saskatchewan, Dept Microbiol & Immunol, 107 Wiggins Rd, Saskatoon, SKS7N 5E5, Canada Univ Saskatchewan 107 Wiggins Rd Saskatoon SK Canada S7N 5E5 anada
Citazione:
W. Xiao et al., "The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways", GENETICS, 155(4), 2000, pp. 1633-1641

Abstract

The RAD6 postreplication repair and mutagenesis pathway is the only major radiation repair pathway yet to be extensively characterized. It has been previously speculated that the RAD6 pathway consists of two parallel subpathways, one error free and another error prone (mutagenic). Here we show thatthe RAD6 group genes can be exclusively divided into three rather than twoindependent subpathways represented by the RAD5, POL30, and REV3 genes; the REV3 pathway is largely mutagenic, whereas the RAD5 and the POL30 pathways are deemed error free. Mutants carrying characteristic mutations in each of the three subpathways are phenotypically indistinguishable from a singlemutant such as rad18, which is defective in the entire RAD6 postreplication repair/tolerance pathway. Furthermore, the rad18 mutation is epistatic toall single or combined mutations in any of the above three subpathways. Our data also suggest that MMS2 and UBC13 play a key role in coordinating theresponse of the error-free subpathways; Mms2 and UbcI3 form a complex required for a novel polyubiquitin chain assembly, which probably serves as a signal transducer to promote both RAD5 and POL30 error-free postreplication repair pathways. The model established by this study will facilitate further research into the molecular mechanisms of postreplication repair and translesion DNA synthesis. In view of the high degree of sequence conservation of the RAD6 pathway genes among all eukaryotes, the model presented in the study may also apply to mammalian cells and predict links to human diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:59:17