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Titolo:
Sip2p and its partner Snf1p kinase affect aging in S-cerevisiae
Autore:
Ashrafi, K; Lin, SS; Manchester, JK; Gordon, JI;
Indirizzi:
Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Pharmacol, St Louis, MO 63110 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 15, volume: 14, anno: 2000,
pagine: 1872 - 1885
SICI:
0890-9369(20000801)14:15<1872:SAIPSK>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIG1 GLUCOSE REPRESSOR; EXTENDED LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; PROTEIN-KINASE; STATIONARY-PHASE; DROSOPHILA-MELANOGASTER; EXTRACHROMOSOMAL RDNA; POSTPONED SENESCENCE; FAMILY MEMBER;
Keywords:
aging; Saccharomyces cervisiae; N-myristoylproteins; Snf1p kinase interacting protein-2; glucose metabolism; cellular energy storage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, JI Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 , St Louis, MO 63110 USA
Citazione:
K. Ashrafi et al., "Sip2p and its partner Snf1p kinase affect aging in S-cerevisiae", GENE DEV, 14(15), 2000, pp. 1872-1885

Abstract

For a number of organisms, the ability to withstand periods of nutrient deprivation correlates directly with lifespan. However, the underlying molecular mechanisms are poorly understood. We show that deletion of the N-myristoylprotein, Sip2p, reduces resistance to nutrient deprivation and shortens lifespan in Saccharomyces cerevisiae. This reduced lifespan is due to accelerated aging, as defined by loss of silencing from telomeres and mating loci, nucleolar fragmentation, and accumulation of extrachromosomal rDNA. Genetic studies indicate that sip2 Delta produces its effect on aging by increasing the activity of Snf1p, a serine/threonine kinase involved in regulating global cellular responses to glucose starvation. Biochemical analyses reveal that as yeast age, hexokinase activity increases as does cellular ATP and NAD(+) content. The change in glucose metabolism represents a new correlate of aging in yeast and occurs to a greater degree, and at earlier generational ages in sip2 Delta cells. Sip2p and Snf1p provide new molecular links between the regulation of cellular energy utilization and aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 07:18:32