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Titolo:
Increased corticotropin-releasing factor concentrations in the bed nucleusof the stria terminalis of anhedonic rats
Autore:
Stout, SC; Mortas, P; Owens, MJ; Nemeroff, CB; Moreau, JL;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 uropsychopharmacol, Atlanta, GA 30322 USA F Hoffmann La Roche & Co Ltd, Preclinical CNS Res, Div Pharma, CH-4070 Basel, Switzerland F Hoffmann La Roche & Co Ltd Basel Switzerland CH-4070 asel, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 401, anno: 2000,
pagine: 39 - 46
SICI:
0014-2999(20000728)401:1<39:ICFCIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MILD STRESS; FACTOR-LIKE IMMUNOREACTIVITY; PARAVENTRICULAR NUCLEUS; DEPRESSED-PATIENTS; FACTOR RECEPTORS; ANIMAL-MODEL; LIFE EVENTS; BRAIN; ANTIDEPRESSANT; PERFORMANCE;
Keywords:
animal model; depression; CRF (corticotropin-releasing factor); bed nucleus of the stria terminalis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Owens, MJ Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Lab Neuropsychopharmacol, 1639 Pierce Dr,Suite 4000, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr,Suite 4000 Atlanta GA USA 30322 22 USA
Citazione:
S.C. Stout et al., "Increased corticotropin-releasing factor concentrations in the bed nucleusof the stria terminalis of anhedonic rats", EUR J PHARM, 401(1), 2000, pp. 39-46

Abstract

Chronic mild stress in rats is an antidepressant-responsive model for anhedonic symptoms of major depression. Many patients with depression exhibit alterations in hypothalamic-pituitary-adrenal axis activity, and corticotropin-releasing factor (CRF) neuronal function. This study investigated the potential involvement of CRF and CRF receptors in the development of chronic mild stress-induced anhedonia in rats. Rats were subjected to 19 days of chronic mild stress, during which time anhedonia was periodically assessed bydetermining the threshold for self-stimulation of the ventral tegmental area. Anhedonic rats exhibited a 50% increase in CRF concentrations in the bed nucleus of the stria terminalis compared to control rats. There were no significant changes in hypothalamic-pituitary-adrenal axis activity, CRF or CRF1 receptor mRNA expression, or CRF receptor binding in the brain regionsanalyzed. Though preliminary, these results are consistent with the hypothesis that chronic stress-induced modulation of CRF function in specific brain structures such as the bed nucleus of the stria terminalis may contribute to the pathophysiology of depression. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:53:13